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Performance of three colposcopic images for the identification of squamous and glandular cervical precursor neoplasias

PURPOSE: To evaluate prevalence and diagnostic performance of three colposcopic images to diagnose squamous and glandular cervical precursor neoplasias. METHODS: Cross-sectional study, conducted through analysis of stored digital colposcopic images. To evaluate the diagnostic performance of three im...

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Autores principales: Fachetti-Machado, Giselle, Figueiredo-Alves, Rosane Ribeiro, Moreira, Marise Amaral Rebouças
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013338/
https://www.ncbi.nlm.nih.gov/pubmed/34727221
http://dx.doi.org/10.1007/s00404-021-06284-4
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author Fachetti-Machado, Giselle
Figueiredo-Alves, Rosane Ribeiro
Moreira, Marise Amaral Rebouças
author_facet Fachetti-Machado, Giselle
Figueiredo-Alves, Rosane Ribeiro
Moreira, Marise Amaral Rebouças
author_sort Fachetti-Machado, Giselle
collection PubMed
description PURPOSE: To evaluate prevalence and diagnostic performance of three colposcopic images to diagnose squamous and glandular cervical precursor neoplasias. METHODS: Cross-sectional study, conducted through analysis of stored digital colposcopic images. To evaluate the diagnostic performance of three images, herein named grouped glands, aceto-white villi, and atypical vessels, for detection of adenocarcinoma in situ (AIS) and cervical squamous intraepithelial neoplasias (CIN) grades 2 and 3, calculations of sensitivity, specificity, accuracy, positive likelihood ratio, receiver operating characteristic (ROC) curve, and area under the curve (AUC) were made, with their respective 95% confidence intervals. RESULTS: Grouped glands, aceto-white villi, and atypical vessels images had: prevalence of 21.3, 53.8, and 33.8% in patients with AIS, and 16.2, 19.5, and 9.3% in those with CIN 2 and 3; for the diagnosis of AIS, sensitivity of 21.3, 53.8, and 33.8%, specificity of 89.8, 95.2, and 94.9%, accuracy of 76.6, 87.2, and 83.1%, positive likelihood ratio of 2.1, 11.2, and 6.6, and AUC of 0.55, 0.74, and 0.64; for the diagnosis of CIN 2 and 3, sensitivity of 16.2, 19.5, and 9.3%, specificity of 89.8, 95.2, and 94.9%, accuracy of 39.4, 43.4, and 36.3%, positive likelihood ratio of 1.6, 4.1, and 1, 8, and AUC of 0.53, 0.57, and 0.52, respectively. CONCLUSION: Prevalence and accuracy of the three images were higher for the diagnosis of glandular than squamous cervical precursor neoplasias. Sensitivity, specificity, positive likelihood, and AUC of aceto-white villi and atypical vessels images were higher for the diagnosis of glandular than squamous cervical precursor neoplasias.
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spelling pubmed-90133382022-05-02 Performance of three colposcopic images for the identification of squamous and glandular cervical precursor neoplasias Fachetti-Machado, Giselle Figueiredo-Alves, Rosane Ribeiro Moreira, Marise Amaral Rebouças Arch Gynecol Obstet Gynecologic Oncology PURPOSE: To evaluate prevalence and diagnostic performance of three colposcopic images to diagnose squamous and glandular cervical precursor neoplasias. METHODS: Cross-sectional study, conducted through analysis of stored digital colposcopic images. To evaluate the diagnostic performance of three images, herein named grouped glands, aceto-white villi, and atypical vessels, for detection of adenocarcinoma in situ (AIS) and cervical squamous intraepithelial neoplasias (CIN) grades 2 and 3, calculations of sensitivity, specificity, accuracy, positive likelihood ratio, receiver operating characteristic (ROC) curve, and area under the curve (AUC) were made, with their respective 95% confidence intervals. RESULTS: Grouped glands, aceto-white villi, and atypical vessels images had: prevalence of 21.3, 53.8, and 33.8% in patients with AIS, and 16.2, 19.5, and 9.3% in those with CIN 2 and 3; for the diagnosis of AIS, sensitivity of 21.3, 53.8, and 33.8%, specificity of 89.8, 95.2, and 94.9%, accuracy of 76.6, 87.2, and 83.1%, positive likelihood ratio of 2.1, 11.2, and 6.6, and AUC of 0.55, 0.74, and 0.64; for the diagnosis of CIN 2 and 3, sensitivity of 16.2, 19.5, and 9.3%, specificity of 89.8, 95.2, and 94.9%, accuracy of 39.4, 43.4, and 36.3%, positive likelihood ratio of 1.6, 4.1, and 1, 8, and AUC of 0.53, 0.57, and 0.52, respectively. CONCLUSION: Prevalence and accuracy of the three images were higher for the diagnosis of glandular than squamous cervical precursor neoplasias. Sensitivity, specificity, positive likelihood, and AUC of aceto-white villi and atypical vessels images were higher for the diagnosis of glandular than squamous cervical precursor neoplasias. Springer Berlin Heidelberg 2021-11-02 2022 /pmc/articles/PMC9013338/ /pubmed/34727221 http://dx.doi.org/10.1007/s00404-021-06284-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Gynecologic Oncology
Fachetti-Machado, Giselle
Figueiredo-Alves, Rosane Ribeiro
Moreira, Marise Amaral Rebouças
Performance of three colposcopic images for the identification of squamous and glandular cervical precursor neoplasias
title Performance of three colposcopic images for the identification of squamous and glandular cervical precursor neoplasias
title_full Performance of three colposcopic images for the identification of squamous and glandular cervical precursor neoplasias
title_fullStr Performance of three colposcopic images for the identification of squamous and glandular cervical precursor neoplasias
title_full_unstemmed Performance of three colposcopic images for the identification of squamous and glandular cervical precursor neoplasias
title_short Performance of three colposcopic images for the identification of squamous and glandular cervical precursor neoplasias
title_sort performance of three colposcopic images for the identification of squamous and glandular cervical precursor neoplasias
topic Gynecologic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013338/
https://www.ncbi.nlm.nih.gov/pubmed/34727221
http://dx.doi.org/10.1007/s00404-021-06284-4
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