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The Danish High-Risk and Resilience Study—VIA 15 – A Study Protocol for the Third Clinical Assessment of a Cohort of 522 Children Born to Parents Diagnosed With Schizophrenia or Bipolar Disorder and Population-Based Controls

BACKGROUND: Children born to parents with severe mental illness have gained more attention during the last decades because of increasing evidence documenting that these children constitute a population with an increased risk of developing mental illness and other negative life outcomes. Because of h...

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Autores principales: Thorup, Anne Amalie Elgaard, Hemager, Nicoline, Bliksted, Vibeke Fuglsang, Greve, Aja Neergaard, Ohland, Jessica, Wilms, Martin, Rohd, Sinnika Birkehøj, Birk, Merete, Bundgaard, Anette Faurskov, Laursen, Andreas Færgemand, Jefsen, Oskar Hougaard, Steffensen, Nanna Lawaetz, Andreassen, Anna Krogh, Veddum, Lotte, Knudsen, Christina Bruun, Enevoldsen, Mette, Nymand, Marie, Brandt, Julie Marie, Søndergaard, Anne, Carmichael, Line, Gregersen, Maja, Krantz, Mette Falkenberg, Burton, Birgitte Klee, Dietz, Martin, Nudel, Ron, Johnsen, Line Korsgaard, Larsen, Kit Melissa, Meder, David, Hulme, Oliver James, Baaré, William Frans Christiaan, Madsen, Kathrine Skak, Lund, Torben Ellegaard, Østergaard, Leif, Juul, Anders, Kjær, Troels Wesenberg, Hjorthøj, Carsten, Siebner, Hartwig Roman, Mors, Ole, Nordentoft, Merete
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013818/
https://www.ncbi.nlm.nih.gov/pubmed/35444571
http://dx.doi.org/10.3389/fpsyt.2022.809807
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author Thorup, Anne Amalie Elgaard
Hemager, Nicoline
Bliksted, Vibeke Fuglsang
Greve, Aja Neergaard
Ohland, Jessica
Wilms, Martin
Rohd, Sinnika Birkehøj
Birk, Merete
Bundgaard, Anette Faurskov
Laursen, Andreas Færgemand
Jefsen, Oskar Hougaard
Steffensen, Nanna Lawaetz
Andreassen, Anna Krogh
Veddum, Lotte
Knudsen, Christina Bruun
Enevoldsen, Mette
Nymand, Marie
Brandt, Julie Marie
Søndergaard, Anne
Carmichael, Line
Gregersen, Maja
Krantz, Mette Falkenberg
Burton, Birgitte Klee
Dietz, Martin
Nudel, Ron
Johnsen, Line Korsgaard
Larsen, Kit Melissa
Meder, David
Hulme, Oliver James
Baaré, William Frans Christiaan
Madsen, Kathrine Skak
Lund, Torben Ellegaard
Østergaard, Leif
Juul, Anders
Kjær, Troels Wesenberg
Hjorthøj, Carsten
Siebner, Hartwig Roman
Mors, Ole
Nordentoft, Merete
author_facet Thorup, Anne Amalie Elgaard
Hemager, Nicoline
Bliksted, Vibeke Fuglsang
Greve, Aja Neergaard
Ohland, Jessica
Wilms, Martin
Rohd, Sinnika Birkehøj
Birk, Merete
Bundgaard, Anette Faurskov
Laursen, Andreas Færgemand
Jefsen, Oskar Hougaard
Steffensen, Nanna Lawaetz
Andreassen, Anna Krogh
Veddum, Lotte
Knudsen, Christina Bruun
Enevoldsen, Mette
Nymand, Marie
Brandt, Julie Marie
Søndergaard, Anne
Carmichael, Line
Gregersen, Maja
Krantz, Mette Falkenberg
Burton, Birgitte Klee
Dietz, Martin
Nudel, Ron
Johnsen, Line Korsgaard
Larsen, Kit Melissa
Meder, David
Hulme, Oliver James
Baaré, William Frans Christiaan
Madsen, Kathrine Skak
Lund, Torben Ellegaard
Østergaard, Leif
Juul, Anders
Kjær, Troels Wesenberg
Hjorthøj, Carsten
Siebner, Hartwig Roman
Mors, Ole
Nordentoft, Merete
author_sort Thorup, Anne Amalie Elgaard
collection PubMed
description BACKGROUND: Children born to parents with severe mental illness have gained more attention during the last decades because of increasing evidence documenting that these children constitute a population with an increased risk of developing mental illness and other negative life outcomes. Because of high-quality research with cohorts of offspring with familial risk and increased knowledge about gene–environment interactions, early interventions and preventive strategies are now being developed all over the world. Adolescence is a period characterized by massive changes, both in terms of physical, neurologic, psychological, social, and behavioral aspects. It is also the period of life with the highest risk of experiencing onset of a mental disorder. Therefore, investigating the impact of various risk and resilience factors in adolescence is important. METHODS: The Danish High-Risk and Resilience Study started data collection in 2012, where 522 7-year-old children were enrolled in the first wave of the study, the VIA 7 study. The cohort was identified through Danish registers based on diagnoses of the parents. A total of 202 children had a parent diagnosed with schizophrenia, 120 children had a parent diagnosed with bipolar disorder, and 200 children had parents without these diagnoses. At age 11 years, all children were assessed for the second time in the VIA 11 study, with a follow-up retention rate of 89%. A comprehensive assessment battery covering domains of psychopathology, neurocognition, social cognition and behavior, motor development and physical health, genetic analyses, attachment, stress, parental functioning, and home environment was carried out at each wave. Magnetic resonance imaging scans of the brain and electroencephalograms were included from age 11 years. This study protocol describes the third wave of assessment, the VIA 15 study, participants being 15 years of age and the full, 3-day-long assessment battery this time including also risk behavior, magnetoencephalography, sleep, and a white noise paradigm. Data collection started on May 1, 2021. DISCUSSION: We will discuss the importance of longitudinal studies and cross-sectional data collection and how studies like this may inform us about unmet needs and windows of opportunity for future preventive interventions, early illness identification, and treatment in the future.
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spelling pubmed-90138182022-04-19 The Danish High-Risk and Resilience Study—VIA 15 – A Study Protocol for the Third Clinical Assessment of a Cohort of 522 Children Born to Parents Diagnosed With Schizophrenia or Bipolar Disorder and Population-Based Controls Thorup, Anne Amalie Elgaard Hemager, Nicoline Bliksted, Vibeke Fuglsang Greve, Aja Neergaard Ohland, Jessica Wilms, Martin Rohd, Sinnika Birkehøj Birk, Merete Bundgaard, Anette Faurskov Laursen, Andreas Færgemand Jefsen, Oskar Hougaard Steffensen, Nanna Lawaetz Andreassen, Anna Krogh Veddum, Lotte Knudsen, Christina Bruun Enevoldsen, Mette Nymand, Marie Brandt, Julie Marie Søndergaard, Anne Carmichael, Line Gregersen, Maja Krantz, Mette Falkenberg Burton, Birgitte Klee Dietz, Martin Nudel, Ron Johnsen, Line Korsgaard Larsen, Kit Melissa Meder, David Hulme, Oliver James Baaré, William Frans Christiaan Madsen, Kathrine Skak Lund, Torben Ellegaard Østergaard, Leif Juul, Anders Kjær, Troels Wesenberg Hjorthøj, Carsten Siebner, Hartwig Roman Mors, Ole Nordentoft, Merete Front Psychiatry Psychiatry BACKGROUND: Children born to parents with severe mental illness have gained more attention during the last decades because of increasing evidence documenting that these children constitute a population with an increased risk of developing mental illness and other negative life outcomes. Because of high-quality research with cohorts of offspring with familial risk and increased knowledge about gene–environment interactions, early interventions and preventive strategies are now being developed all over the world. Adolescence is a period characterized by massive changes, both in terms of physical, neurologic, psychological, social, and behavioral aspects. It is also the period of life with the highest risk of experiencing onset of a mental disorder. Therefore, investigating the impact of various risk and resilience factors in adolescence is important. METHODS: The Danish High-Risk and Resilience Study started data collection in 2012, where 522 7-year-old children were enrolled in the first wave of the study, the VIA 7 study. The cohort was identified through Danish registers based on diagnoses of the parents. A total of 202 children had a parent diagnosed with schizophrenia, 120 children had a parent diagnosed with bipolar disorder, and 200 children had parents without these diagnoses. At age 11 years, all children were assessed for the second time in the VIA 11 study, with a follow-up retention rate of 89%. A comprehensive assessment battery covering domains of psychopathology, neurocognition, social cognition and behavior, motor development and physical health, genetic analyses, attachment, stress, parental functioning, and home environment was carried out at each wave. Magnetic resonance imaging scans of the brain and electroencephalograms were included from age 11 years. This study protocol describes the third wave of assessment, the VIA 15 study, participants being 15 years of age and the full, 3-day-long assessment battery this time including also risk behavior, magnetoencephalography, sleep, and a white noise paradigm. Data collection started on May 1, 2021. DISCUSSION: We will discuss the importance of longitudinal studies and cross-sectional data collection and how studies like this may inform us about unmet needs and windows of opportunity for future preventive interventions, early illness identification, and treatment in the future. Frontiers Media S.A. 2022-04-04 /pmc/articles/PMC9013818/ /pubmed/35444571 http://dx.doi.org/10.3389/fpsyt.2022.809807 Text en Copyright © 2022 Thorup, Hemager, Bliksted, Greve, Ohland, Wilms, Rohd, Birk, Bundgaard, Laursen, Jefsen, Steffensen, Andreassen, Veddum, Knudsen, Enevoldsen, Nymand, Brandt, Søndergaard, Carmichael, Gregersen, Krantz, Burton, Dietz, Nudel, Johnsen, Larsen, Meder, Hulme, Baaré, Madsen, Lund, Østergaard, Juul, Kjær, Hjorthøj, Siebner, Mors and Nordentoft. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Thorup, Anne Amalie Elgaard
Hemager, Nicoline
Bliksted, Vibeke Fuglsang
Greve, Aja Neergaard
Ohland, Jessica
Wilms, Martin
Rohd, Sinnika Birkehøj
Birk, Merete
Bundgaard, Anette Faurskov
Laursen, Andreas Færgemand
Jefsen, Oskar Hougaard
Steffensen, Nanna Lawaetz
Andreassen, Anna Krogh
Veddum, Lotte
Knudsen, Christina Bruun
Enevoldsen, Mette
Nymand, Marie
Brandt, Julie Marie
Søndergaard, Anne
Carmichael, Line
Gregersen, Maja
Krantz, Mette Falkenberg
Burton, Birgitte Klee
Dietz, Martin
Nudel, Ron
Johnsen, Line Korsgaard
Larsen, Kit Melissa
Meder, David
Hulme, Oliver James
Baaré, William Frans Christiaan
Madsen, Kathrine Skak
Lund, Torben Ellegaard
Østergaard, Leif
Juul, Anders
Kjær, Troels Wesenberg
Hjorthøj, Carsten
Siebner, Hartwig Roman
Mors, Ole
Nordentoft, Merete
The Danish High-Risk and Resilience Study—VIA 15 – A Study Protocol for the Third Clinical Assessment of a Cohort of 522 Children Born to Parents Diagnosed With Schizophrenia or Bipolar Disorder and Population-Based Controls
title The Danish High-Risk and Resilience Study—VIA 15 – A Study Protocol for the Third Clinical Assessment of a Cohort of 522 Children Born to Parents Diagnosed With Schizophrenia or Bipolar Disorder and Population-Based Controls
title_full The Danish High-Risk and Resilience Study—VIA 15 – A Study Protocol for the Third Clinical Assessment of a Cohort of 522 Children Born to Parents Diagnosed With Schizophrenia or Bipolar Disorder and Population-Based Controls
title_fullStr The Danish High-Risk and Resilience Study—VIA 15 – A Study Protocol for the Third Clinical Assessment of a Cohort of 522 Children Born to Parents Diagnosed With Schizophrenia or Bipolar Disorder and Population-Based Controls
title_full_unstemmed The Danish High-Risk and Resilience Study—VIA 15 – A Study Protocol for the Third Clinical Assessment of a Cohort of 522 Children Born to Parents Diagnosed With Schizophrenia or Bipolar Disorder and Population-Based Controls
title_short The Danish High-Risk and Resilience Study—VIA 15 – A Study Protocol for the Third Clinical Assessment of a Cohort of 522 Children Born to Parents Diagnosed With Schizophrenia or Bipolar Disorder and Population-Based Controls
title_sort danish high-risk and resilience study—via 15 – a study protocol for the third clinical assessment of a cohort of 522 children born to parents diagnosed with schizophrenia or bipolar disorder and population-based controls
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013818/
https://www.ncbi.nlm.nih.gov/pubmed/35444571
http://dx.doi.org/10.3389/fpsyt.2022.809807
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AT kjærtroelswesenberg danishhighriskandresiliencestudyvia15astudyprotocolforthethirdclinicalassessmentofacohortof522childrenborntoparentsdiagnosedwithschizophreniaorbipolardisorderandpopulationbasedcontrols
AT hjorthøjcarsten danishhighriskandresiliencestudyvia15astudyprotocolforthethirdclinicalassessmentofacohortof522childrenborntoparentsdiagnosedwithschizophreniaorbipolardisorderandpopulationbasedcontrols
AT siebnerhartwigroman danishhighriskandresiliencestudyvia15astudyprotocolforthethirdclinicalassessmentofacohortof522childrenborntoparentsdiagnosedwithschizophreniaorbipolardisorderandpopulationbasedcontrols
AT morsole danishhighriskandresiliencestudyvia15astudyprotocolforthethirdclinicalassessmentofacohortof522childrenborntoparentsdiagnosedwithschizophreniaorbipolardisorderandpopulationbasedcontrols
AT nordentoftmerete danishhighriskandresiliencestudyvia15astudyprotocolforthethirdclinicalassessmentofacohortof522childrenborntoparentsdiagnosedwithschizophreniaorbipolardisorderandpopulationbasedcontrols