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Previous SARS-CoV-2 Infection Status Among the Current RT-PCR-Positive Individuals Affected During the Second Wave of COVID-19 Infections in Chennai, India

India witnessed a very strong second wave of coronavirus disease 2019 (COVID-19) during March and June 2021. Newly emerging variants of concern can escape immunity and cause reinfection. We tested newly diagnosed COVID-19 cases during the second wave in Chennai, India for the presence of Immunoglobu...

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Autores principales: Thangaraj, Jeromie Wesley Vivian, Kumar, Muthusamy Santhosh, Kumar, C. P. Girish, Yadav, Pragya, Rani, D. Sudha, Karunakaran, T., Murhekar, Manoj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013836/
https://www.ncbi.nlm.nih.gov/pubmed/35444976
http://dx.doi.org/10.3389/fpubh.2022.836454
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author Thangaraj, Jeromie Wesley Vivian
Kumar, Muthusamy Santhosh
Kumar, C. P. Girish
Yadav, Pragya
Rani, D. Sudha
Karunakaran, T.
Murhekar, Manoj
author_facet Thangaraj, Jeromie Wesley Vivian
Kumar, Muthusamy Santhosh
Kumar, C. P. Girish
Yadav, Pragya
Rani, D. Sudha
Karunakaran, T.
Murhekar, Manoj
author_sort Thangaraj, Jeromie Wesley Vivian
collection PubMed
description India witnessed a very strong second wave of coronavirus disease 2019 (COVID-19) during March and June 2021. Newly emerging variants of concern can escape immunity and cause reinfection. We tested newly diagnosed COVID-19 cases during the second wave in Chennai, India for the presence of Immunoglobulin G (IgG) antibodies to estimate the extent of re-infection. Of the 902 unvaccinated COVID-19 positive individuals, 53 (26.5%) were reactive for IgG antibodies and non-reactive for Immunogobulin M (IgM) antibodies. Among the 53 IgG-positive individuals, the interval between symptom onset (or last contact with the known case in case of asymptomatic) was <5 days in 29 individuals, ≥5 days in 11 individuals, while 13 asymptomatic individuals did not know their last contact with a positive case. The possible re-infections ranged between 3.2% (95% CI: 2.2–4.5%) and 4.3% (95% CI: 3.4–6.2%). The findings indicate that re-infection was not a major reason of the surge in cases during second wave. The IgG seropositivity among recently diagnosed unvaccinated COVID-19 patients could provide early indications about the extent of re-infections in the area.
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spelling pubmed-90138362022-04-19 Previous SARS-CoV-2 Infection Status Among the Current RT-PCR-Positive Individuals Affected During the Second Wave of COVID-19 Infections in Chennai, India Thangaraj, Jeromie Wesley Vivian Kumar, Muthusamy Santhosh Kumar, C. P. Girish Yadav, Pragya Rani, D. Sudha Karunakaran, T. Murhekar, Manoj Front Public Health Public Health India witnessed a very strong second wave of coronavirus disease 2019 (COVID-19) during March and June 2021. Newly emerging variants of concern can escape immunity and cause reinfection. We tested newly diagnosed COVID-19 cases during the second wave in Chennai, India for the presence of Immunoglobulin G (IgG) antibodies to estimate the extent of re-infection. Of the 902 unvaccinated COVID-19 positive individuals, 53 (26.5%) were reactive for IgG antibodies and non-reactive for Immunogobulin M (IgM) antibodies. Among the 53 IgG-positive individuals, the interval between symptom onset (or last contact with the known case in case of asymptomatic) was <5 days in 29 individuals, ≥5 days in 11 individuals, while 13 asymptomatic individuals did not know their last contact with a positive case. The possible re-infections ranged between 3.2% (95% CI: 2.2–4.5%) and 4.3% (95% CI: 3.4–6.2%). The findings indicate that re-infection was not a major reason of the surge in cases during second wave. The IgG seropositivity among recently diagnosed unvaccinated COVID-19 patients could provide early indications about the extent of re-infections in the area. Frontiers Media S.A. 2022-04-04 /pmc/articles/PMC9013836/ /pubmed/35444976 http://dx.doi.org/10.3389/fpubh.2022.836454 Text en Copyright © 2022 Thangaraj, Kumar, Kumar, Yadav, Rani, Karunakaran and Murhekar. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Thangaraj, Jeromie Wesley Vivian
Kumar, Muthusamy Santhosh
Kumar, C. P. Girish
Yadav, Pragya
Rani, D. Sudha
Karunakaran, T.
Murhekar, Manoj
Previous SARS-CoV-2 Infection Status Among the Current RT-PCR-Positive Individuals Affected During the Second Wave of COVID-19 Infections in Chennai, India
title Previous SARS-CoV-2 Infection Status Among the Current RT-PCR-Positive Individuals Affected During the Second Wave of COVID-19 Infections in Chennai, India
title_full Previous SARS-CoV-2 Infection Status Among the Current RT-PCR-Positive Individuals Affected During the Second Wave of COVID-19 Infections in Chennai, India
title_fullStr Previous SARS-CoV-2 Infection Status Among the Current RT-PCR-Positive Individuals Affected During the Second Wave of COVID-19 Infections in Chennai, India
title_full_unstemmed Previous SARS-CoV-2 Infection Status Among the Current RT-PCR-Positive Individuals Affected During the Second Wave of COVID-19 Infections in Chennai, India
title_short Previous SARS-CoV-2 Infection Status Among the Current RT-PCR-Positive Individuals Affected During the Second Wave of COVID-19 Infections in Chennai, India
title_sort previous sars-cov-2 infection status among the current rt-pcr-positive individuals affected during the second wave of covid-19 infections in chennai, india
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013836/
https://www.ncbi.nlm.nih.gov/pubmed/35444976
http://dx.doi.org/10.3389/fpubh.2022.836454
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