Efficient targeting of NY-ESO-1 tumor antigen to human cDC1s by lymphotactin results in cross-presentation and antigen-specific T cell expansion

BACKGROUND: Type 1 conventional dendritic cells (cDC1s) are characterized by their ability to induce potent CD8(+) T cell responses. In efforts to generate novel vaccination strategies, notably against cancer, human cDC1s emerge as an ideal target to deliver antigens. cDC1s uniquely express XCR1, a...

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Detalles Bibliográficos
Autores principales: Le Gall, Camille, Cammarata, Anna, de Haas, Lukas, Ramos-Tomillero, Iván, Cuenca-Escalona, Jorge, Schouren, Kayleigh, Wijfjes, Zacharias, Becker, Anouk M D, Bödder, Johanna, Dölen, Yusuf, de Vries, I Jolanda M, Figdor, Carl G, Flórez-Grau, Georgina, Verdoes, Martijn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014073/
https://www.ncbi.nlm.nih.gov/pubmed/35428705
http://dx.doi.org/10.1136/jitc-2021-004309

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