PD-1 Targeted Nanoparticles Inhibit Activated T Cells and Alleviate Autoimmunity via Suppression of Cellular Energy Metabolism Mediated by PKM2

BACKGROUND: Effector T cells, especially T helper 1 (Th1) cells and T helper 17 (Th17) cells, are involved in the pathogenesis of many autoimmune diseases such as uveitis. Under hyperactive immune conditions, these effector T cells pathologically maintain a high expression level of programmed cell d...

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Detalles Bibliográficos
Autores principales: Liu, Zhangluxi, Xu, Jing, Li, Hongxi, Shu, Jia, Su, Guannan, Zhou, Chunjiang, Yang, Peizeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014113/
https://www.ncbi.nlm.nih.gov/pubmed/35444416
http://dx.doi.org/10.2147/IJN.S349360

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