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Human genetic admixture through the lens of population genomics
Over the past 50 years, geneticists have made great strides in understanding how our species' evolutionary history gave rise to current patterns of human genetic diversity classically summarized by Lewontin in his 1972 paper, ‘The Apportionment of Human Diversity’. One evolutionary process that...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Royal Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014191/ https://www.ncbi.nlm.nih.gov/pubmed/35430881 http://dx.doi.org/10.1098/rstb.2020.0410 |
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author | Gopalan, Shyamalika Smith, Samuel Pattillo Korunes, Katharine Hamid, Iman Ramachandran, Sohini Goldberg, Amy |
author_facet | Gopalan, Shyamalika Smith, Samuel Pattillo Korunes, Katharine Hamid, Iman Ramachandran, Sohini Goldberg, Amy |
author_sort | Gopalan, Shyamalika |
collection | PubMed |
description | Over the past 50 years, geneticists have made great strides in understanding how our species' evolutionary history gave rise to current patterns of human genetic diversity classically summarized by Lewontin in his 1972 paper, ‘The Apportionment of Human Diversity’. One evolutionary process that requires special attention in both population genetics and statistical genetics is admixture: gene flow between two or more previously separated source populations to form a new admixed population. The admixture process introduces ancestry-based structure into patterns of genetic variation within and between populations, which in turn influences the inference of demographic histories, identification of genetic targets of selection and prediction of complex traits. In this review, we outline some challenges for admixture population genetics, including limitations of applying methods designed for populations without recent admixture to the study of admixed populations. We highlight recent studies and methodological advances that aim to overcome such challenges, leveraging genomic signatures of admixture that occurred in the past tens of generations to gain insights into human history, natural selection and complex trait architecture. This article is part of the theme issue ‘Celebrating 50 years since Lewontin's apportionment of human diversity’. |
format | Online Article Text |
id | pubmed-9014191 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-90141912022-04-21 Human genetic admixture through the lens of population genomics Gopalan, Shyamalika Smith, Samuel Pattillo Korunes, Katharine Hamid, Iman Ramachandran, Sohini Goldberg, Amy Philos Trans R Soc Lond B Biol Sci Articles Over the past 50 years, geneticists have made great strides in understanding how our species' evolutionary history gave rise to current patterns of human genetic diversity classically summarized by Lewontin in his 1972 paper, ‘The Apportionment of Human Diversity’. One evolutionary process that requires special attention in both population genetics and statistical genetics is admixture: gene flow between two or more previously separated source populations to form a new admixed population. The admixture process introduces ancestry-based structure into patterns of genetic variation within and between populations, which in turn influences the inference of demographic histories, identification of genetic targets of selection and prediction of complex traits. In this review, we outline some challenges for admixture population genetics, including limitations of applying methods designed for populations without recent admixture to the study of admixed populations. We highlight recent studies and methodological advances that aim to overcome such challenges, leveraging genomic signatures of admixture that occurred in the past tens of generations to gain insights into human history, natural selection and complex trait architecture. This article is part of the theme issue ‘Celebrating 50 years since Lewontin's apportionment of human diversity’. The Royal Society 2022-06-06 2022-04-18 /pmc/articles/PMC9014191/ /pubmed/35430881 http://dx.doi.org/10.1098/rstb.2020.0410 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Articles Gopalan, Shyamalika Smith, Samuel Pattillo Korunes, Katharine Hamid, Iman Ramachandran, Sohini Goldberg, Amy Human genetic admixture through the lens of population genomics |
title | Human genetic admixture through the lens of population genomics |
title_full | Human genetic admixture through the lens of population genomics |
title_fullStr | Human genetic admixture through the lens of population genomics |
title_full_unstemmed | Human genetic admixture through the lens of population genomics |
title_short | Human genetic admixture through the lens of population genomics |
title_sort | human genetic admixture through the lens of population genomics |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014191/ https://www.ncbi.nlm.nih.gov/pubmed/35430881 http://dx.doi.org/10.1098/rstb.2020.0410 |
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