Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis

Atherosclerosis (AS) is universally defined as chronic vascular inflammation induced by dyslipidaemia, obesity, hypertension, diabetes and other risk factors. Extracellular vesicles as information transmitters regulate intracellular interactions and their important cargo circular RNAs are involved i...

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Autores principales: Wen, Cheng, Li, Bowei, Nie, Lei, Mao, Ling, Xia, Yuanpeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014218/
https://www.ncbi.nlm.nih.gov/pubmed/35445015
http://dx.doi.org/10.3389/fcell.2022.804247
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author Wen, Cheng
Li, Bowei
Nie, Lei
Mao, Ling
Xia, Yuanpeng
author_facet Wen, Cheng
Li, Bowei
Nie, Lei
Mao, Ling
Xia, Yuanpeng
author_sort Wen, Cheng
collection PubMed
description Atherosclerosis (AS) is universally defined as chronic vascular inflammation induced by dyslipidaemia, obesity, hypertension, diabetes and other risk factors. Extracellular vesicles as information transmitters regulate intracellular interactions and their important cargo circular RNAs are involved in the pathological process of AS. In this review, we summarize the current data to elucidate the emerging roles of extracellular vesicle-derived circular RNAs (EV-circRNAs) in AS and the mechanism by which EV-circRNAs affect the development of AS. Additionally, we discuss their vital role in the progression from risk factors to AS and highlight their great potential for use as diagnostic biomarkers of and novel therapeutic strategies for AS.
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spelling pubmed-90142182022-04-19 Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis Wen, Cheng Li, Bowei Nie, Lei Mao, Ling Xia, Yuanpeng Front Cell Dev Biol Cell and Developmental Biology Atherosclerosis (AS) is universally defined as chronic vascular inflammation induced by dyslipidaemia, obesity, hypertension, diabetes and other risk factors. Extracellular vesicles as information transmitters regulate intracellular interactions and their important cargo circular RNAs are involved in the pathological process of AS. In this review, we summarize the current data to elucidate the emerging roles of extracellular vesicle-derived circular RNAs (EV-circRNAs) in AS and the mechanism by which EV-circRNAs affect the development of AS. Additionally, we discuss their vital role in the progression from risk factors to AS and highlight their great potential for use as diagnostic biomarkers of and novel therapeutic strategies for AS. Frontiers Media S.A. 2022-04-04 /pmc/articles/PMC9014218/ /pubmed/35445015 http://dx.doi.org/10.3389/fcell.2022.804247 Text en Copyright © 2022 Wen, Li, Nie, Mao and Xia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Wen, Cheng
Li, Bowei
Nie, Lei
Mao, Ling
Xia, Yuanpeng
Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis
title Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis
title_full Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis
title_fullStr Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis
title_full_unstemmed Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis
title_short Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis
title_sort emerging roles of extracellular vesicle-delivered circular rnas in atherosclerosis
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014218/
https://www.ncbi.nlm.nih.gov/pubmed/35445015
http://dx.doi.org/10.3389/fcell.2022.804247
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