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Effect of Factor H on Complement Alternative Pathway Activation in Human Serum Remains on Porcine Cells Lacking N-Glycolylneuraminic Acid

BACKGROUND: Triple knockout (TKO) donor pigs lacking alpha-1,3-galactose (Gal), N-glycolylneuraminic acid (Neu5Gc), and Sd(a) expressions were developed to improve the clinical success of xenotransplantation. Neu5Gc, a sialic acid expressed on cell surfaces, recruits factor H to protect cells from a...

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Detalles Bibliográficos
Autores principales:	Lee, Haneulnari, Park, Eun Mi, Ko, Nayoung, Choi, Kimyung, Oh, Keon Bong, Kang, Hee Jung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014258/ https://www.ncbi.nlm.nih.gov/pubmed/35444661 http://dx.doi.org/10.3389/fimmu.2022.859261

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