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Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for “Diabesity”

[Image: see text] Peptidic agonists of the glucagon-like peptide-1 receptor (GLP-1R) have gained a prominent role in the therapy of type-2 diabetes and are being considered for reducing food intake in obesity. Potential advantages of small molecules acting as positive allosteric modulators (PAMs) of...

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Detalles Bibliográficos
Autores principales:	Decara, Juan M., Vázquez-Villa, Henar, Brea, José, Alonso, Mónica, Srivastava, Raj Kamal, Orio, Laura, Alén, Francisco, Suárez, Juan, Baixeras, Elena, García-Cárceles, Javier, Escobar-Peña, Andrea, Lutz, Beat, Rodríguez, Ramón, Codesido, Eva, Garcia-Ladona, F. Javier, Bennett, Teresa A., Ballesteros, Juan A., Cruces, Jacobo, Loza, María I., Benhamú, Bellinda, Rodríguez de Fonseca, Fernando, López-Rodríguez, María L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014410/ https://www.ncbi.nlm.nih.gov/pubmed/35349261 http://dx.doi.org/10.1021/acs.jmedchem.1c01842

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