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Rapamycin improves the quality and developmental competence of mice oocytes by promoting DNA damage repair during in vitro maturation

BACKGROUND: Increasing evidence has shown that the mammalian target of rapamycin (mTOR) pathway plays a critical role in oocyte meiosis and embryonic development, however, previous studies reporting the effects of rapamycin on oocyte IVM showed different or even opposite results, and the specific me...

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Detalles Bibliográficos
Autores principales: Yang, Qiyu, Xi, Qingsong, Wang, Meng, Long, Rui, Hu, Juan, Li, Zhou, Ren, Xinling, Zhu, Lixia, Jin, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014618/
https://www.ncbi.nlm.nih.gov/pubmed/35436937
http://dx.doi.org/10.1186/s12958-022-00943-0