EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model

Natural killer (NK) cells exhibit antifibrotic properties in liver fibrosis (LF) by suppressing activated hepatic stellate cell (HSC) populations. Prostaglandin E(2) (PGE(2)) plays a dual role in innate and adaptive immunity. Here, we found that E-prostanoid 3 receptor (EP3) was markedly downregulat...

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Detalles Bibliográficos
Autores principales: Tao, Xixi, Zhang, Rui, Du, Ronglu, Yu, Tingting, Yang, Hui, Li, Jiwen, Wang, Yuhong, Liu, Qian, Zuo, Shengkai, Wang, Xi, Lazarus, Michael, Zhou, Lu, Wang, Bangmao, Yu, Ying, Shen, Yujun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014794/
https://www.ncbi.nlm.nih.gov/pubmed/35420633
http://dx.doi.org/10.1084/jem.20212414

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