Disruption of Hyaluronic Acid in Skeletal Muscle Induces Decreased Voluntary Activity via Chemosensitive Muscle Afferent Sensitization in Male Mice

PEGPH20, a human recombinant hyaluronidase, has been proposed as a coadjutant to pancreatic cancer chemotherapy. In early trials, patients reported increased widespread muscle pain as the main adverse reaction to PEGPH20. To understand how PEGPH20 caused musculoskeletal pain, we systemically adminis...

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Detalles Bibliográficos
Autores principales: Queme, Luis F., J. Dourson, Adam, Hofmann, Megan C., Butterfield, Ally, Paladini, Rudolph D., Jankowski, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2022
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014980/
https://www.ncbi.nlm.nih.gov/pubmed/35387844
http://dx.doi.org/10.1523/ENEURO.0522-21.2022

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