Cargando…

Synthetic role of miR‐200b‐3p, ABCD(2) score, and carotid ultrasound in the prediction of cerebral infarction in patients with transient ischemic attack

BACKGROUND: Transient ischemic attack (TIA) is a major risk factor for the occurrence of cerebral infarction (CI). This study aimed to evaluate the predictive value of the synthetic role of miR‐200b‐3p, ABCD(2) score, and carotid ultrasound for CI onset in patients with TIA. METHODS: Expression of m...

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Jiwei, Wang, Zhirong, Li, Na, Zhang, Xiaomeng, Huo, Xiaoguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014995/
https://www.ncbi.nlm.nih.gov/pubmed/35261213
http://dx.doi.org/10.1002/brb3.2518
_version_ 1784688291450191872
author Zheng, Jiwei
Wang, Zhirong
Li, Na
Zhang, Xiaomeng
Huo, Xiaoguang
author_facet Zheng, Jiwei
Wang, Zhirong
Li, Na
Zhang, Xiaomeng
Huo, Xiaoguang
author_sort Zheng, Jiwei
collection PubMed
description BACKGROUND: Transient ischemic attack (TIA) is a major risk factor for the occurrence of cerebral infarction (CI). This study aimed to evaluate the predictive value of the synthetic role of miR‐200b‐3p, ABCD(2) score, and carotid ultrasound for CI onset in patients with TIA. METHODS: Expression of miR‐200b‐3p was detected by reverse transcription quantitative PCR and carotid stenosis degree was evaluated using carotid ultrasound examination. Association of miR‐200b‐3p with ABCD(2) scores and carotid stenosis degree was assessed using t‐test and chi‐square test. Logistic regression analysis was used to judge the ability of miR‐200b‐3p, ABCD(2) score, and carotid ultrasound to predict the occurrence of CI. Receiver operating characteristic curve was used to analyze the diagnostic value of miR‐200b‐3p and the accuracy of miR‐200b‐3p, ABCD(2) score, and carotid ultrasound in predicting CI development. RESULTS: Expression of serum miR‐200b‐3p was significantly increased in TIA patients compared with healthy controls, and had diagnostic value in TIA patients. Serum miR‐200b‐3p was significantly associated with dyslipidemia, ABCD(2) score, and carotid stenosis degree in TIA patients. ABCD(2) score, carotid stenosis degree, and serum miR‐200b‐3p were independently associated with CI onset, and the synthetic role of these three indicators had the best accuracy in the prediction of CI onset in TIA patients. CONCLUSION: Serum miR‐200b‐3p expression was increased in TIA patients with considerable diagnostic value to screen TIA cases from healthy controls. Moreover, we speculated that the combination of miR‐200b‐3p, ABCD(2) score, and carotid stenosis degree by ultrasound may propose as an efficient predictive strategy for the prediction of CI in TIA patients.
format Online
Article
Text
id pubmed-9014995
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-90149952022-04-20 Synthetic role of miR‐200b‐3p, ABCD(2) score, and carotid ultrasound in the prediction of cerebral infarction in patients with transient ischemic attack Zheng, Jiwei Wang, Zhirong Li, Na Zhang, Xiaomeng Huo, Xiaoguang Brain Behav Original Articles BACKGROUND: Transient ischemic attack (TIA) is a major risk factor for the occurrence of cerebral infarction (CI). This study aimed to evaluate the predictive value of the synthetic role of miR‐200b‐3p, ABCD(2) score, and carotid ultrasound for CI onset in patients with TIA. METHODS: Expression of miR‐200b‐3p was detected by reverse transcription quantitative PCR and carotid stenosis degree was evaluated using carotid ultrasound examination. Association of miR‐200b‐3p with ABCD(2) scores and carotid stenosis degree was assessed using t‐test and chi‐square test. Logistic regression analysis was used to judge the ability of miR‐200b‐3p, ABCD(2) score, and carotid ultrasound to predict the occurrence of CI. Receiver operating characteristic curve was used to analyze the diagnostic value of miR‐200b‐3p and the accuracy of miR‐200b‐3p, ABCD(2) score, and carotid ultrasound in predicting CI development. RESULTS: Expression of serum miR‐200b‐3p was significantly increased in TIA patients compared with healthy controls, and had diagnostic value in TIA patients. Serum miR‐200b‐3p was significantly associated with dyslipidemia, ABCD(2) score, and carotid stenosis degree in TIA patients. ABCD(2) score, carotid stenosis degree, and serum miR‐200b‐3p were independently associated with CI onset, and the synthetic role of these three indicators had the best accuracy in the prediction of CI onset in TIA patients. CONCLUSION: Serum miR‐200b‐3p expression was increased in TIA patients with considerable diagnostic value to screen TIA cases from healthy controls. Moreover, we speculated that the combination of miR‐200b‐3p, ABCD(2) score, and carotid stenosis degree by ultrasound may propose as an efficient predictive strategy for the prediction of CI in TIA patients. John Wiley and Sons Inc. 2022-03-09 /pmc/articles/PMC9014995/ /pubmed/35261213 http://dx.doi.org/10.1002/brb3.2518 Text en © 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Zheng, Jiwei
Wang, Zhirong
Li, Na
Zhang, Xiaomeng
Huo, Xiaoguang
Synthetic role of miR‐200b‐3p, ABCD(2) score, and carotid ultrasound in the prediction of cerebral infarction in patients with transient ischemic attack
title Synthetic role of miR‐200b‐3p, ABCD(2) score, and carotid ultrasound in the prediction of cerebral infarction in patients with transient ischemic attack
title_full Synthetic role of miR‐200b‐3p, ABCD(2) score, and carotid ultrasound in the prediction of cerebral infarction in patients with transient ischemic attack
title_fullStr Synthetic role of miR‐200b‐3p, ABCD(2) score, and carotid ultrasound in the prediction of cerebral infarction in patients with transient ischemic attack
title_full_unstemmed Synthetic role of miR‐200b‐3p, ABCD(2) score, and carotid ultrasound in the prediction of cerebral infarction in patients with transient ischemic attack
title_short Synthetic role of miR‐200b‐3p, ABCD(2) score, and carotid ultrasound in the prediction of cerebral infarction in patients with transient ischemic attack
title_sort synthetic role of mir‐200b‐3p, abcd(2) score, and carotid ultrasound in the prediction of cerebral infarction in patients with transient ischemic attack
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014995/
https://www.ncbi.nlm.nih.gov/pubmed/35261213
http://dx.doi.org/10.1002/brb3.2518
work_keys_str_mv AT zhengjiwei syntheticroleofmir200b3pabcd2scoreandcarotidultrasoundinthepredictionofcerebralinfarctioninpatientswithtransientischemicattack
AT wangzhirong syntheticroleofmir200b3pabcd2scoreandcarotidultrasoundinthepredictionofcerebralinfarctioninpatientswithtransientischemicattack
AT lina syntheticroleofmir200b3pabcd2scoreandcarotidultrasoundinthepredictionofcerebralinfarctioninpatientswithtransientischemicattack
AT zhangxiaomeng syntheticroleofmir200b3pabcd2scoreandcarotidultrasoundinthepredictionofcerebralinfarctioninpatientswithtransientischemicattack
AT huoxiaoguang syntheticroleofmir200b3pabcd2scoreandcarotidultrasoundinthepredictionofcerebralinfarctioninpatientswithtransientischemicattack