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Genetics of osteopontin in patients with chronic kidney disease: The German Chronic Kidney Disease study

Osteopontin (OPN), encoded by SPP1, is a phosphorylated glycoprotein predominantly synthesized in kidney tissue. Increased OPN mRNA and protein expression correlates with proteinuria, reduced creatinine clearance, and kidney fibrosis in animal models of kidney disease. But its genetic underpinnings...

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Detalles Bibliográficos
Autores principales:	Cheng, Yurong, Li, Yong, Scherer, Nora, Grundner-Culemann, Franziska, Lehtimäki, Terho, Mishra, Binisha H., Raitakari, Olli T., Nauck, Matthias, Eckardt, Kai-Uwe, Sekula, Peggy, Schultheiss, Ulla T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015153/ https://www.ncbi.nlm.nih.gov/pubmed/35385482 http://dx.doi.org/10.1371/journal.pgen.1010139

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