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Genomic, immunological, and clinical analysis of COVID‐19 vaccine breakthrough infections in Beijing, China
As the coronavirus disease 2019 (COVID‐19) pandemic is still ongoing and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants are circulating worldwide, an increasing number of breakthrough infections are being detected despite the good efficacy of COVID‐19 vaccines. Data on 88 COVI...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015436/ https://www.ncbi.nlm.nih.gov/pubmed/35112366 http://dx.doi.org/10.1002/jmv.27636 |
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author | Tian, Di Song, Yang Zhang, Man Pan, Yang Ge, Ziruo Zhang, Yao Ren, Xingxiang Wen, Jing Xu, Yanli Guo, Hong Yang, Peng Chen, Zhihai Xu, Wenbo |
author_facet | Tian, Di Song, Yang Zhang, Man Pan, Yang Ge, Ziruo Zhang, Yao Ren, Xingxiang Wen, Jing Xu, Yanli Guo, Hong Yang, Peng Chen, Zhihai Xu, Wenbo |
author_sort | Tian, Di |
collection | PubMed |
description | As the coronavirus disease 2019 (COVID‐19) pandemic is still ongoing and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants are circulating worldwide, an increasing number of breakthrough infections are being detected despite the good efficacy of COVID‐19 vaccines. Data on 88 COVID‐19 breakthrough cases (breakthrough infections group) and 41 unvaccinated cases (unvaccinated group) from June 1 to August 22, 2021, were extracted from a cloud database established at Beijing Ditan Hospital to evaluate the clinical, immunological, and genomic characteristics of COVID‐19 breakthrough infections. Among these 129 COVID‐19 cases, 33 whole genomes were successfully sequenced, of which 23 were Delta variants, including 15 from the breakthrough infections group. Asymptomatic and mild cases predominated in both groups, but two patients developed severe disease in the unvaccinated group. The median time of viral shedding in the breakthrough infections group was significantly lower than that in the unvaccinated group (p = 0.003). In the breakthrough infections group, the IgG titers showed a significantly increasing trend (p = 0.007), and the CD4 + T lymphocyte count was significantly elevated (p = 0.018). For people infected with the Delta variant in the two groups, no significant difference was observed in either the quantitative reverse‐transcription polymerase chain reaction results or viral shedding time. In conclusion, among vaccinated patients, the cases of COVID‐19 vaccine breakthrough infections were mainly asymptomatic and mild, IgG titers were significantly increased and rose rapidly, and the viral shedding time was shorter. |
format | Online Article Text |
id | pubmed-9015436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90154362022-04-19 Genomic, immunological, and clinical analysis of COVID‐19 vaccine breakthrough infections in Beijing, China Tian, Di Song, Yang Zhang, Man Pan, Yang Ge, Ziruo Zhang, Yao Ren, Xingxiang Wen, Jing Xu, Yanli Guo, Hong Yang, Peng Chen, Zhihai Xu, Wenbo J Med Virol Research Articles As the coronavirus disease 2019 (COVID‐19) pandemic is still ongoing and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants are circulating worldwide, an increasing number of breakthrough infections are being detected despite the good efficacy of COVID‐19 vaccines. Data on 88 COVID‐19 breakthrough cases (breakthrough infections group) and 41 unvaccinated cases (unvaccinated group) from June 1 to August 22, 2021, were extracted from a cloud database established at Beijing Ditan Hospital to evaluate the clinical, immunological, and genomic characteristics of COVID‐19 breakthrough infections. Among these 129 COVID‐19 cases, 33 whole genomes were successfully sequenced, of which 23 were Delta variants, including 15 from the breakthrough infections group. Asymptomatic and mild cases predominated in both groups, but two patients developed severe disease in the unvaccinated group. The median time of viral shedding in the breakthrough infections group was significantly lower than that in the unvaccinated group (p = 0.003). In the breakthrough infections group, the IgG titers showed a significantly increasing trend (p = 0.007), and the CD4 + T lymphocyte count was significantly elevated (p = 0.018). For people infected with the Delta variant in the two groups, no significant difference was observed in either the quantitative reverse‐transcription polymerase chain reaction results or viral shedding time. In conclusion, among vaccinated patients, the cases of COVID‐19 vaccine breakthrough infections were mainly asymptomatic and mild, IgG titers were significantly increased and rose rapidly, and the viral shedding time was shorter. John Wiley and Sons Inc. 2022-02-11 2022-05 /pmc/articles/PMC9015436/ /pubmed/35112366 http://dx.doi.org/10.1002/jmv.27636 Text en © 2022 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Tian, Di Song, Yang Zhang, Man Pan, Yang Ge, Ziruo Zhang, Yao Ren, Xingxiang Wen, Jing Xu, Yanli Guo, Hong Yang, Peng Chen, Zhihai Xu, Wenbo Genomic, immunological, and clinical analysis of COVID‐19 vaccine breakthrough infections in Beijing, China |
title | Genomic, immunological, and clinical analysis of COVID‐19 vaccine breakthrough infections in Beijing, China |
title_full | Genomic, immunological, and clinical analysis of COVID‐19 vaccine breakthrough infections in Beijing, China |
title_fullStr | Genomic, immunological, and clinical analysis of COVID‐19 vaccine breakthrough infections in Beijing, China |
title_full_unstemmed | Genomic, immunological, and clinical analysis of COVID‐19 vaccine breakthrough infections in Beijing, China |
title_short | Genomic, immunological, and clinical analysis of COVID‐19 vaccine breakthrough infections in Beijing, China |
title_sort | genomic, immunological, and clinical analysis of covid‐19 vaccine breakthrough infections in beijing, china |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015436/ https://www.ncbi.nlm.nih.gov/pubmed/35112366 http://dx.doi.org/10.1002/jmv.27636 |
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