Anti‐SARS‐CoV‐2 Inhibitory Profile of New Quinoline Compounds in Cell Culture‐Based Infection Models

The presently ongoing pandemic of human SARS‐CoV‐2 infections (COVID‐19) presents an enormous challenge in surveillance, vaccine and antiviral drug development. Here we report the synthesis of new bioactive quinoline‐morpholine hybrid compounds and their virological evaluation, which proves pronounc...

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Detalles Bibliográficos
Autores principales: Herrmann, Lars, Hahn, Friedrich, Wangen, Christina, Marschall, Manfred, Tsogoeva, Svetlana B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015527/
https://www.ncbi.nlm.nih.gov/pubmed/34859926
http://dx.doi.org/10.1002/chem.202103861
Descripción
Sumario:The presently ongoing pandemic of human SARS‐CoV‐2 infections (COVID‐19) presents an enormous challenge in surveillance, vaccine and antiviral drug development. Here we report the synthesis of new bioactive quinoline‐morpholine hybrid compounds and their virological evaluation, which proves pronounced cell culture‐based inhibitory profile against SARS‐CoV‐2. Thus, selected quinoline compounds may suggest specific hit‐to‐lead development.

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