Anti‐SARS‐CoV‐2 Inhibitory Profile of New Quinoline Compounds in Cell Culture‐Based Infection Models

The presently ongoing pandemic of human SARS‐CoV‐2 infections (COVID‐19) presents an enormous challenge in surveillance, vaccine and antiviral drug development. Here we report the synthesis of new bioactive quinoline‐morpholine hybrid compounds and their virological evaluation, which proves pronounc...

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Autores principales: Herrmann, Lars, Hahn, Friedrich, Wangen, Christina, Marschall, Manfred, Tsogoeva, Svetlana B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015527/
https://www.ncbi.nlm.nih.gov/pubmed/34859926
http://dx.doi.org/10.1002/chem.202103861
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author Herrmann, Lars
Hahn, Friedrich
Wangen, Christina
Marschall, Manfred
Tsogoeva, Svetlana B.
author_facet Herrmann, Lars
Hahn, Friedrich
Wangen, Christina
Marschall, Manfred
Tsogoeva, Svetlana B.
author_sort Herrmann, Lars
collection PubMed
description The presently ongoing pandemic of human SARS‐CoV‐2 infections (COVID‐19) presents an enormous challenge in surveillance, vaccine and antiviral drug development. Here we report the synthesis of new bioactive quinoline‐morpholine hybrid compounds and their virological evaluation, which proves pronounced cell culture‐based inhibitory profile against SARS‐CoV‐2. Thus, selected quinoline compounds may suggest specific hit‐to‐lead development.
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spelling pubmed-90155272022-04-19 Anti‐SARS‐CoV‐2 Inhibitory Profile of New Quinoline Compounds in Cell Culture‐Based Infection Models Herrmann, Lars Hahn, Friedrich Wangen, Christina Marschall, Manfred Tsogoeva, Svetlana B. Chemistry Research Articles The presently ongoing pandemic of human SARS‐CoV‐2 infections (COVID‐19) presents an enormous challenge in surveillance, vaccine and antiviral drug development. Here we report the synthesis of new bioactive quinoline‐morpholine hybrid compounds and their virological evaluation, which proves pronounced cell culture‐based inhibitory profile against SARS‐CoV‐2. Thus, selected quinoline compounds may suggest specific hit‐to‐lead development. John Wiley and Sons Inc. 2021-12-29 2022-01-19 /pmc/articles/PMC9015527/ /pubmed/34859926 http://dx.doi.org/10.1002/chem.202103861 Text en © 2021 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Herrmann, Lars
Hahn, Friedrich
Wangen, Christina
Marschall, Manfred
Tsogoeva, Svetlana B.
Anti‐SARS‐CoV‐2 Inhibitory Profile of New Quinoline Compounds in Cell Culture‐Based Infection Models
title Anti‐SARS‐CoV‐2 Inhibitory Profile of New Quinoline Compounds in Cell Culture‐Based Infection Models
title_full Anti‐SARS‐CoV‐2 Inhibitory Profile of New Quinoline Compounds in Cell Culture‐Based Infection Models
title_fullStr Anti‐SARS‐CoV‐2 Inhibitory Profile of New Quinoline Compounds in Cell Culture‐Based Infection Models
title_full_unstemmed Anti‐SARS‐CoV‐2 Inhibitory Profile of New Quinoline Compounds in Cell Culture‐Based Infection Models
title_short Anti‐SARS‐CoV‐2 Inhibitory Profile of New Quinoline Compounds in Cell Culture‐Based Infection Models
title_sort anti‐sars‐cov‐2 inhibitory profile of new quinoline compounds in cell culture‐based infection models
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015527/
https://www.ncbi.nlm.nih.gov/pubmed/34859926
http://dx.doi.org/10.1002/chem.202103861
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