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Household Transmission and Symptomology of Severe Acute Respiratory Syndrome Coronavirus 2 Alpha Variant among Children—California and Colorado, 2021

OBJECTIVE: To assess the household secondary infection risk (SIR) of B.1.1.7 (Alpha) and non-Alpha lineages of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among children. STUDY DESIGN: During January to April 2021, we prospectively followed households with a SARS-CoV-2 infection. We...

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Autores principales: Waltenburg, Michelle A., Whaley, Melissa J., Chancey, Rebecca J., Donnelly, Marisa A.P., Chuey, Meagan R., Soto, Raymond, Schwartz, Noah G., Chu, Victoria T., Sleweon, Sadia, McCormick, David W., Uehara, Anna, Retchless, Adam C., Tong, Suxiang, Folster, Jennifer M., Petway, Marla, Thornburg, Natalie J., Drobeniuc, Jan, Austin, Brett, Hudziec, Meghan M., Stringer, Ginger, Albanese, Bernadette A., Totten, Sarah E., Matzinger, Shannon R., Staples, J. Erin, Killerby, Marie E., Hughes, Laura J., Matanock, Almea, Beatty, Mark, Tate, Jacqueline E., Kirking, Hannah L., Hsu, Christopher H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mosby 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015725/
https://www.ncbi.nlm.nih.gov/pubmed/35447121
http://dx.doi.org/10.1016/j.jpeds.2022.04.032
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author Waltenburg, Michelle A.
Whaley, Melissa J.
Chancey, Rebecca J.
Donnelly, Marisa A.P.
Chuey, Meagan R.
Soto, Raymond
Schwartz, Noah G.
Chu, Victoria T.
Sleweon, Sadia
McCormick, David W.
Uehara, Anna
Retchless, Adam C.
Tong, Suxiang
Folster, Jennifer M.
Petway, Marla
Thornburg, Natalie J.
Drobeniuc, Jan
Austin, Brett
Hudziec, Meghan M.
Stringer, Ginger
Albanese, Bernadette A.
Totten, Sarah E.
Matzinger, Shannon R.
Staples, J. Erin
Killerby, Marie E.
Hughes, Laura J.
Matanock, Almea
Beatty, Mark
Tate, Jacqueline E.
Kirking, Hannah L.
Hsu, Christopher H.
author_facet Waltenburg, Michelle A.
Whaley, Melissa J.
Chancey, Rebecca J.
Donnelly, Marisa A.P.
Chuey, Meagan R.
Soto, Raymond
Schwartz, Noah G.
Chu, Victoria T.
Sleweon, Sadia
McCormick, David W.
Uehara, Anna
Retchless, Adam C.
Tong, Suxiang
Folster, Jennifer M.
Petway, Marla
Thornburg, Natalie J.
Drobeniuc, Jan
Austin, Brett
Hudziec, Meghan M.
Stringer, Ginger
Albanese, Bernadette A.
Totten, Sarah E.
Matzinger, Shannon R.
Staples, J. Erin
Killerby, Marie E.
Hughes, Laura J.
Matanock, Almea
Beatty, Mark
Tate, Jacqueline E.
Kirking, Hannah L.
Hsu, Christopher H.
author_sort Waltenburg, Michelle A.
collection PubMed
description OBJECTIVE: To assess the household secondary infection risk (SIR) of B.1.1.7 (Alpha) and non-Alpha lineages of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among children. STUDY DESIGN: During January to April 2021, we prospectively followed households with a SARS-CoV-2 infection. We collected questionnaires, serial nasopharyngeal swabs for reverse transcription polymerase chain reaction testing and whole genome sequencing, and serial blood samples for serology testing. We calculated SIRs by primary case age (pediatric vs adult), household contact age, and viral lineage. We evaluated risk factors associated with transmission and described symptom profiles among children. RESULTS: Among 36 households with pediatric primary cases, 21 (58%) had secondary infections. Among 91 households with adult primary cases, 51 (56%) had secondary infections. SIRs among pediatric and adult primary cases were 45% and 54%, respectively (OR, 0.79; 95% CI, 0.41-1.54). SIRs among pediatric primary cases with Alpha and non-Alpha lineage were 55% and 46%, respectively (OR, 1.52; 95% CI, 0.51-4.53). SIRs among pediatric and adult household contacts were 55% and 49%, respectively (OR, 1.01; 95% CI, 0.68-1.50). Among pediatric contacts, no significant differences in the odds of acquiring infection by demographic or household characteristics were observed. CONCLUSIONS: Household transmission of SARS-CoV-2 from children and adult primary cases to household members was frequent. The risk of secondary infection was similar among child and adult household contacts. Among children, household transmission of SARS-CoV-2 and the risk of secondary infection was not influenced by lineage. Continued mitigation strategies (eg, masking, physical distancing, vaccination) are needed to protect at-risk groups regardless of virus lineage circulating in communities.
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spelling pubmed-90157252022-04-19 Household Transmission and Symptomology of Severe Acute Respiratory Syndrome Coronavirus 2 Alpha Variant among Children—California and Colorado, 2021 Waltenburg, Michelle A. Whaley, Melissa J. Chancey, Rebecca J. Donnelly, Marisa A.P. Chuey, Meagan R. Soto, Raymond Schwartz, Noah G. Chu, Victoria T. Sleweon, Sadia McCormick, David W. Uehara, Anna Retchless, Adam C. Tong, Suxiang Folster, Jennifer M. Petway, Marla Thornburg, Natalie J. Drobeniuc, Jan Austin, Brett Hudziec, Meghan M. Stringer, Ginger Albanese, Bernadette A. Totten, Sarah E. Matzinger, Shannon R. Staples, J. Erin Killerby, Marie E. Hughes, Laura J. Matanock, Almea Beatty, Mark Tate, Jacqueline E. Kirking, Hannah L. Hsu, Christopher H. J Pediatr Original Article OBJECTIVE: To assess the household secondary infection risk (SIR) of B.1.1.7 (Alpha) and non-Alpha lineages of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among children. STUDY DESIGN: During January to April 2021, we prospectively followed households with a SARS-CoV-2 infection. We collected questionnaires, serial nasopharyngeal swabs for reverse transcription polymerase chain reaction testing and whole genome sequencing, and serial blood samples for serology testing. We calculated SIRs by primary case age (pediatric vs adult), household contact age, and viral lineage. We evaluated risk factors associated with transmission and described symptom profiles among children. RESULTS: Among 36 households with pediatric primary cases, 21 (58%) had secondary infections. Among 91 households with adult primary cases, 51 (56%) had secondary infections. SIRs among pediatric and adult primary cases were 45% and 54%, respectively (OR, 0.79; 95% CI, 0.41-1.54). SIRs among pediatric primary cases with Alpha and non-Alpha lineage were 55% and 46%, respectively (OR, 1.52; 95% CI, 0.51-4.53). SIRs among pediatric and adult household contacts were 55% and 49%, respectively (OR, 1.01; 95% CI, 0.68-1.50). Among pediatric contacts, no significant differences in the odds of acquiring infection by demographic or household characteristics were observed. CONCLUSIONS: Household transmission of SARS-CoV-2 from children and adult primary cases to household members was frequent. The risk of secondary infection was similar among child and adult household contacts. Among children, household transmission of SARS-CoV-2 and the risk of secondary infection was not influenced by lineage. Continued mitigation strategies (eg, masking, physical distancing, vaccination) are needed to protect at-risk groups regardless of virus lineage circulating in communities. Mosby 2022-08 2022-04-18 /pmc/articles/PMC9015725/ /pubmed/35447121 http://dx.doi.org/10.1016/j.jpeds.2022.04.032 Text en Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Waltenburg, Michelle A.
Whaley, Melissa J.
Chancey, Rebecca J.
Donnelly, Marisa A.P.
Chuey, Meagan R.
Soto, Raymond
Schwartz, Noah G.
Chu, Victoria T.
Sleweon, Sadia
McCormick, David W.
Uehara, Anna
Retchless, Adam C.
Tong, Suxiang
Folster, Jennifer M.
Petway, Marla
Thornburg, Natalie J.
Drobeniuc, Jan
Austin, Brett
Hudziec, Meghan M.
Stringer, Ginger
Albanese, Bernadette A.
Totten, Sarah E.
Matzinger, Shannon R.
Staples, J. Erin
Killerby, Marie E.
Hughes, Laura J.
Matanock, Almea
Beatty, Mark
Tate, Jacqueline E.
Kirking, Hannah L.
Hsu, Christopher H.
Household Transmission and Symptomology of Severe Acute Respiratory Syndrome Coronavirus 2 Alpha Variant among Children—California and Colorado, 2021
title Household Transmission and Symptomology of Severe Acute Respiratory Syndrome Coronavirus 2 Alpha Variant among Children—California and Colorado, 2021
title_full Household Transmission and Symptomology of Severe Acute Respiratory Syndrome Coronavirus 2 Alpha Variant among Children—California and Colorado, 2021
title_fullStr Household Transmission and Symptomology of Severe Acute Respiratory Syndrome Coronavirus 2 Alpha Variant among Children—California and Colorado, 2021
title_full_unstemmed Household Transmission and Symptomology of Severe Acute Respiratory Syndrome Coronavirus 2 Alpha Variant among Children—California and Colorado, 2021
title_short Household Transmission and Symptomology of Severe Acute Respiratory Syndrome Coronavirus 2 Alpha Variant among Children—California and Colorado, 2021
title_sort household transmission and symptomology of severe acute respiratory syndrome coronavirus 2 alpha variant among children—california and colorado, 2021
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015725/
https://www.ncbi.nlm.nih.gov/pubmed/35447121
http://dx.doi.org/10.1016/j.jpeds.2022.04.032
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