MYL-1402O: A Bevacizumab Biosimilar

MYL-1402O (Abevmy(®), Lextemy(®)) is a biosimilar of the reference anti-vascular endothelial growth factor antibody bevacizumab. Abevmy(®) is approved for use in all indications for which reference bevacizumab is approved, including the treatment of non-small cell lung cancer (NSCLC) and other solid cancers. Lextemy(®) is approved for all indications as reference bevacizumab, except in recurrent ovarian cancer. MYL-1402O has similar physicochemical and pharmacodynamic properties to those of reference bevacizumab, and the pharmacokinetic similarity of the agents has been shown in healthy male subjects. MYL-1402O demonstrated clinical efficacy equivalent to that of reference bevacizumab in patients with non-squamous NSCLC. The tolerability, safety and immunogenicity profiles of MYL-1402O were consistent with those of reference bevacizumab. The role of reference bevacizumab in the management of solid cancers is well established and MYL-1402O provides an effective biosimilar alternative for patients requiring bevacizumab therapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11523-021-00858-7.