Gene Co-expression Analysis of the Human Substantia Nigra Identifies ZNHIT1 as an SNCA Co-expressed Gene that Protects Against α-Synuclein-Induced Impairments in Neurite Growth and Mitochondrial Dysfunction in SH-SY5Y Cells

Parkinson’s disease (PD) is neurodegenerative disorder with the pathological hallmarks of progressive degeneration of midbrain dopaminergic neurons from the substantia nigra (SN), and accumulation and spread of inclusions of aggregated α-synuclein (α-Syn). Since current PD therapies do not prevent n...

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Detalles Bibliográficos
Autores principales: McCarthy, Erin, Barron, Aaron, Morales-Prieto, Noelia, Mazzocchi, Martina, McCarthy, Cathal M., Collins, Louise M., Sullivan, Aideen M., O’Keeffe, Gerard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016026/
https://www.ncbi.nlm.nih.gov/pubmed/35175558
http://dx.doi.org/10.1007/s12035-022-02768-9

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