Cargando…

Mesenchymal stem cells empower T cells in the lymph nodes via MCP-1/PD-L1 axis

Mesenchymal stem cells (MSCs) are a type of immunosuppressive stromal cell found in multiple tissues and organs. However, whether MSCs possess immunosupportive characteristics remains unclear. In this study, we showed that the lymph nodes contain immunosupportive MSCs. They produce and secrete a hig...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Yifan, Qu, Yan, Meng, Bowen, Huang, Weiying, Tang, Jianxia, Wang, Runci, Chen, Zetao, Kou, Xiaoxing, Shi, Songtao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016066/ https://www.ncbi.nlm.nih.gov/pubmed/35436982 http://dx.doi.org/10.1038/s41419-022-04822-9

Ejemplares similares

PD-1 Expression by Lymph Node and Intratumoral Regulatory T Cells Is Associated with Lymph Node Metastasis in Pancreatic Cancer
por: Seifert, Adrian M., et al.
Publicado: (2020)

Mechanical force-driven TNFα endocytosis governs stem cell homeostasis
por: Yu, Wenjing, et al.
Publicado: (2021)

Lymph node migratory dendritic cells modulate HIV-1 transcription through PD-1 engagement
por: Banga, Riddhima, et al.
Publicado: (2019)

High PD-1 expression on regulatory and effector T-cells in lung cancer draining lymph nodes
por: van de Ven, Rieneke, et al.
Publicado: (2017)

Outcomes with adjuvant anti-PD-1 therapy in patients with sentinel lymph node-positive melanoma without completion lymph node dissection
por: Eroglu, Zeynep, et al.
Publicado: (2022)

TRPV1 and the MCP-1/CCR2 Axis Modulate Post-UTI Chronic Pain
por: Rosen, John M., et al.
Publicado: (2018)

PD-1(+) CD8(+) T cells are exhausted in tumours and functional in draining lymph nodes of colorectal cancer patients
por: Wu, X, et al.
Publicado: (2014)

PD-L1(+) lung cancer stem cells modify the metastatic lymph-node immunomicroenvironment in nsclc patients
por: Raniszewska, A., et al.
Publicado: (2020)

Increased levels of PD1 and glycolysis in CD4(+) T cells are positively associated with lymph node metastasis in OSCC
por: Wu, Kun, et al.
Publicado: (2023)

Expression of PD-1/PD-L1 axis in mediastinal lymph nodes and lung tissue of human and experimental lung fibrosis indicates a potential therapeutic target for idiopathic pulmonary fibrosis
por: Karampitsakos, Theodoros, et al.
Publicado: (2023)

Tumor-draining lymph node-derived tumor-specific memory CD8(+) T cells: a key player in PD-1/PD-L1 immunotherapy
por: Yin, Enzhi, et al.
Publicado: (2023)

Phagocyte Chemoattraction Is Induced through the Mcp-1–Ccr2 Axis during Efferocytosis
por: Lee, Sang-Ah, et al.
Publicado: (2021)

Role of MCP-1/CCR2 axis in renal fibrosis: Mechanisms and therapeutic targeting
por: He, Shiyang, et al.
Publicado: (2023)

IP-10, MCP-1, MCP-2, MCP-3, and IL-1RA hold promise as biomarkers for infection with M. tuberculosis in a whole blood based T-cell assay
por: Ruhwald, Morten, et al.
Publicado: (2009)

Effect of Flavonoids on MCP-1 Expression in Human Coronary Artery Endothelial Cells and Impact on MCP-1-Dependent Migration of Human Monocytes
por: Brüser, Lea, et al.
Publicado: (2023)

Mathematical Modeling Reveals That the Administration of EGF Can Promote the Elimination of Lymph Node Metastases by PD-1/PD-L1 Blockade
por: Benchaib, Mohamed Amine, et al.
Publicado: (2019)

Expression of PD-1/PD-L1 in primary breast tumours and metastatic axillary lymph nodes and its correlation with clinicopathological parameters
por: Yuan, Chenxi, et al.
Publicado: (2019)

The correlation of serum sPD-1 and sPD-L1 levels with clinical, pathological characteristics and lymph node metastasis in nonsmall cell lung cancer patients
por: ANCIN, Burcu, et al.
Publicado: (2022)

CD32(+) and PD-1(+) Lymph Node CD4 T Cells Support Persistent HIV-1 Transcription in Treated Aviremic Individuals
por: Noto, Alessandra, et al.
Publicado: (2018)

Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses
por: Das, Suvendu, et al.
Publicado: (2013)

Interactions of MCP1 with Components of the Replication Machinery in Mammalian Cells
por: Bronze-da-Rocha, Elsa, et al.
Publicado: (2011)

Enlarged Mediastinal Lymph Nodes in Computed Tomography are a Valuable Prognostic Factor in Non-Small Cell Lung Cancer Patients with Pathologically Negative Lymph Nodes
por: Zheng, Yuansheng, et al.
Publicado: (2020)

Intracellular claudin‐1 at the invasive front of tongue squamous cell carcinoma is associated with lymph node metastasis
por: Yamamoto, Daisuke, et al.
Publicado: (2019)

Neutrophils Which Migrate to Lymph Nodes Modulate CD4(+) T Cell Response by a PD-L1 Dependent Mechanism
por: Castell, Sofía D., et al.
Publicado: (2019)

Tumour-draining lymph nodes in head and neck cancer are characterized by accumulation of CTLA-4 and PD-1 expressing Treg cells
por: Piersiala, Krzysztof, et al.
Publicado: (2022)

Proteomic analysis of MSC‐derived apoptotic vesicles identifies Fas inheritance to ameliorate haemophilia a via activating platelet functions
por: Zhang, Xiao, et al.
Publicado: (2022)

Central neck lymph node metastasis in oral squamous cell carcinoma at the floor of mouth
por: Zhang, Songtao, et al.
Publicado: (2021)

Prevalence of lymph node and maximum short axis in traumatic patients
por: Karami, Mehdi, et al.
Publicado: (2018)

PD-L1 expression in regional lymph nodes and predictable roles in anti-cancer immune responses
por: Komohara, Yoshihiro, et al.
Publicado: (2020)

PD-L1 Expression Is an Independent Marker for Lymph Node Metastasis in Middle Eastern Endometrial Cancer
por: Siraj, Abdul K., et al.
Publicado: (2021)

PD-L1/PD-1 Axis in Glioblastoma Multiforme
por: Litak, Jakub, et al.
Publicado: (2019)

The PD-1:PD-L1 axis in Inflammatory Arthritis
por: Canavan, Mary, et al.
Publicado: (2021)

PD-1/PD-L1 axis in organ fibrosis
por: Zhao, Youliang, et al.
Publicado: (2023)

The CLEC-2–podoplanin axis controls fibroblastic reticular cell contractility and lymph node microarchitecture
por: Astarita, Jillian L., et al.
Publicado: (2014)

LncRNA MRF drives the regulatory function on monocyte recruitment and polarization through HNRNPD-MCP1 axis in mesenchymal stem cells
por: Lin, Jiajie, et al.
Publicado: (2022)

Quantitative MRI cell tracking of immune cell recruitment to tumors and draining lymph nodes in response to anti-PD-1 and a DPX-based immunotherapy
por: Tremblay, Marie-Laurence, et al.
Publicado: (2020)

Experimental hypersensitivity pneumonitis: role of MCP-1()
por: Schuyler, Mark, et al.
Publicado: (2003)

MCP-1: Function, regulation, and involvement in disease
por: Singh, Sanjiv, et al.
Publicado: (2021)

Pb Induces MCP-1 in the Choroid Plexus
por: Gu, Huiying, et al.
Publicado: (2022)

N1 lymph node detection in lymph node harvesting in non-small cell lung cancer: Formaldehyde exposure is a drawback?
por: Citak, Sevinc, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_amrsqpbg713hin9bh9uva1evh1