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Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort

Post-transplant diabetes mellitus (PTDM) is associated with a higher risk of adverse outcomes. We aimed to describe the proportion of patients with diabetes prior to solid organ transplantation (SOT) and post-transplant diabetes mellitus (PTDM) in three time periods (early-likely PTDM: 0–45 days; 46...

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Autores principales: Dos Santos, Quenia, Hornum,  Mads, Terrones-Campos, Cynthia, Crone, Cornelia Geisler, Wareham, Neval Ete, Soeborg, Andreas, Rasmussen, Allan, Gustafsson, Finn, Perch, Michael, Soerensen, Soeren Schwartz, Lundgren, Jens, Feldt-Rasmussen,  Bo, Reekie, Joanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016119/
https://www.ncbi.nlm.nih.gov/pubmed/35449717
http://dx.doi.org/10.3389/ti.2022.10352
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author Dos Santos, Quenia
Hornum,  Mads
Terrones-Campos, Cynthia
Crone, Cornelia Geisler
Wareham, Neval Ete
Soeborg, Andreas
Rasmussen, Allan
Gustafsson, Finn
Perch, Michael
Soerensen, Soeren Schwartz
Lundgren, Jens
Feldt-Rasmussen,  Bo
Reekie, Joanne
author_facet Dos Santos, Quenia
Hornum,  Mads
Terrones-Campos, Cynthia
Crone, Cornelia Geisler
Wareham, Neval Ete
Soeborg, Andreas
Rasmussen, Allan
Gustafsson, Finn
Perch, Michael
Soerensen, Soeren Schwartz
Lundgren, Jens
Feldt-Rasmussen,  Bo
Reekie, Joanne
author_sort Dos Santos, Quenia
collection PubMed
description Post-transplant diabetes mellitus (PTDM) is associated with a higher risk of adverse outcomes. We aimed to describe the proportion of patients with diabetes prior to solid organ transplantation (SOT) and post-transplant diabetes mellitus (PTDM) in three time periods (early-likely PTDM: 0–45 days; 46–365 days and >365 days) post-transplant and to estimate possible risk factors associated with PTDM in each time-period. Additionally, we compared the risk of death and causes of death in patients with diabetes prior to transplant, PTDM, and non-diabetes patients. A total of 959 SOT recipients (heart, lung, liver, and kidney) transplanted at University Hospital of Copenhagen between 2010 and 2015 were included. The highest PTDM incidence was observed at 46–365 days after transplant in all SOT recipients. Age and the Charlson Comorbidity Index (CCI Score) in all time periods were the two most important risk factors for PTDM. Compared to non-diabetes patients, SOT recipients with pre-transplant diabetes and PTDM patients had a higher risk of all-cause mortality death (aHR: 1.77, 95% CI: 1.16–2.69 and aHR: 1.89, 95% CI: 1.17–3.06 respectively). Pre-transplant diabetes and PTDM patients had a higher risk of death due to cardiovascular diseases and cancer, respectively, when compared to non-diabetes patients.
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spelling pubmed-90161192022-04-20 Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort Dos Santos, Quenia Hornum,  Mads Terrones-Campos, Cynthia Crone, Cornelia Geisler Wareham, Neval Ete Soeborg, Andreas Rasmussen, Allan Gustafsson, Finn Perch, Michael Soerensen, Soeren Schwartz Lundgren, Jens Feldt-Rasmussen,  Bo Reekie, Joanne Transpl Int Health Archive Post-transplant diabetes mellitus (PTDM) is associated with a higher risk of adverse outcomes. We aimed to describe the proportion of patients with diabetes prior to solid organ transplantation (SOT) and post-transplant diabetes mellitus (PTDM) in three time periods (early-likely PTDM: 0–45 days; 46–365 days and >365 days) post-transplant and to estimate possible risk factors associated with PTDM in each time-period. Additionally, we compared the risk of death and causes of death in patients with diabetes prior to transplant, PTDM, and non-diabetes patients. A total of 959 SOT recipients (heart, lung, liver, and kidney) transplanted at University Hospital of Copenhagen between 2010 and 2015 were included. The highest PTDM incidence was observed at 46–365 days after transplant in all SOT recipients. Age and the Charlson Comorbidity Index (CCI Score) in all time periods were the two most important risk factors for PTDM. Compared to non-diabetes patients, SOT recipients with pre-transplant diabetes and PTDM patients had a higher risk of all-cause mortality death (aHR: 1.77, 95% CI: 1.16–2.69 and aHR: 1.89, 95% CI: 1.17–3.06 respectively). Pre-transplant diabetes and PTDM patients had a higher risk of death due to cardiovascular diseases and cancer, respectively, when compared to non-diabetes patients. Frontiers Media S.A. 2022-04-05 /pmc/articles/PMC9016119/ /pubmed/35449717 http://dx.doi.org/10.3389/ti.2022.10352 Text en Copyright © 2022 Dos Santos, Hornum, Terrones-Campos, Crone, Wareham, Soeborg, Rasmussen, Gustafsson, Perch, Soerensen, Lundgren, Feldt-Rasmussen and Reekie. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Health Archive
Dos Santos, Quenia
Hornum,  Mads
Terrones-Campos, Cynthia
Crone, Cornelia Geisler
Wareham, Neval Ete
Soeborg, Andreas
Rasmussen, Allan
Gustafsson, Finn
Perch, Michael
Soerensen, Soeren Schwartz
Lundgren, Jens
Feldt-Rasmussen,  Bo
Reekie, Joanne
Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort
title Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort
title_full Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort
title_fullStr Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort
title_full_unstemmed Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort
title_short Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort
title_sort posttransplantation diabetes mellitus among solid organ recipients in a danish cohort
topic Health Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016119/
https://www.ncbi.nlm.nih.gov/pubmed/35449717
http://dx.doi.org/10.3389/ti.2022.10352
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