Characterization of Chelation and Absorption of Calcium by a Mytilus edulis Derived Osteogenic Peptide

In a previous study, the peptide LGKDQVRT, which was identified by enzymatic hydrolysis, released during the proteolysis of Mytilus edulis, had potential osteogenic activity. In this study, the octapeptide LGKDQVRT was able to spontaneously bind calcium in a 1:1 stoichiometric ratio, and the calcium...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Zhe, Han, Shiying, Chen, Hui, Zhu, Zhixuan, Han, Lingyu, Dong, Xiufang, Du, Ming, Li, Tingting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Nutrition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016177/
https://www.ncbi.nlm.nih.gov/pubmed/35449539
http://dx.doi.org/10.3389/fnut.2022.840638
_version_ 1784688473041534976
author Xu, Zhe
Han, Shiying
Chen, Hui
Zhu, Zhixuan
Han, Lingyu
Dong, Xiufang
Du, Ming
Li, Tingting
author_facet Xu, Zhe
Han, Shiying
Chen, Hui
Zhu, Zhixuan
Han, Lingyu
Dong, Xiufang
Du, Ming
Li, Tingting
author_sort Xu, Zhe
collection PubMed
description In a previous study, the peptide LGKDQVRT, which was identified by enzymatic hydrolysis, released during the proteolysis of Mytilus edulis, had potential osteogenic activity. In this study, the octapeptide LGKDQVRT was able to spontaneously bind calcium in a 1:1 stoichiometric ratio, and the calcium-binding site likely involves calcium and amino acid VAL6 in the LGKDQVRT peptide to form a metal-donor to metal acceptor complex. The peptide LGKDQVRT has the activity of promoting the proliferation and differentiation of osteoblasts. The results of this study suggest that hydrolyzed peptides from Mytilus edulis protein can be used as a dietary supplement to improve calcium absorption and prevent osteoporosis.
format Online
Article
Text
id pubmed-9016177
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-90161772022-04-20 Characterization of Chelation and Absorption of Calcium by a Mytilus edulis Derived Osteogenic Peptide Xu, Zhe Han, Shiying Chen, Hui Zhu, Zhixuan Han, Lingyu Dong, Xiufang Du, Ming Li, Tingting Front Nutr Nutrition In a previous study, the peptide LGKDQVRT, which was identified by enzymatic hydrolysis, released during the proteolysis of Mytilus edulis, had potential osteogenic activity. In this study, the octapeptide LGKDQVRT was able to spontaneously bind calcium in a 1:1 stoichiometric ratio, and the calcium-binding site likely involves calcium and amino acid VAL6 in the LGKDQVRT peptide to form a metal-donor to metal acceptor complex. The peptide LGKDQVRT has the activity of promoting the proliferation and differentiation of osteoblasts. The results of this study suggest that hydrolyzed peptides from Mytilus edulis protein can be used as a dietary supplement to improve calcium absorption and prevent osteoporosis. Frontiers Media S.A. 2022-04-05 /pmc/articles/PMC9016177/ /pubmed/35449539 http://dx.doi.org/10.3389/fnut.2022.840638 Text en Copyright © 2022 Xu, Chen, Zhu, Han, Dong, Du and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Xu, Zhe
Han, Shiying
Chen, Hui
Zhu, Zhixuan
Han, Lingyu
Dong, Xiufang
Du, Ming
Li, Tingting
Characterization of Chelation and Absorption of Calcium by a Mytilus edulis Derived Osteogenic Peptide
title Characterization of Chelation and Absorption of Calcium by a Mytilus edulis Derived Osteogenic Peptide
title_full Characterization of Chelation and Absorption of Calcium by a Mytilus edulis Derived Osteogenic Peptide
title_fullStr Characterization of Chelation and Absorption of Calcium by a Mytilus edulis Derived Osteogenic Peptide
title_full_unstemmed Characterization of Chelation and Absorption of Calcium by a Mytilus edulis Derived Osteogenic Peptide
title_short Characterization of Chelation and Absorption of Calcium by a Mytilus edulis Derived Osteogenic Peptide
title_sort characterization of chelation and absorption of calcium by a mytilus edulis derived osteogenic peptide
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016177/
https://www.ncbi.nlm.nih.gov/pubmed/35449539
http://dx.doi.org/10.3389/fnut.2022.840638
work_keys_str_mv AT xuzhe characterizationofchelationandabsorptionofcalciumbyamytilusedulisderivedosteogenicpeptide
AT hanshiying characterizationofchelationandabsorptionofcalciumbyamytilusedulisderivedosteogenicpeptide
AT chenhui characterizationofchelationandabsorptionofcalciumbyamytilusedulisderivedosteogenicpeptide
AT zhuzhixuan characterizationofchelationandabsorptionofcalciumbyamytilusedulisderivedosteogenicpeptide
AT hanlingyu characterizationofchelationandabsorptionofcalciumbyamytilusedulisderivedosteogenicpeptide
AT dongxiufang characterizationofchelationandabsorptionofcalciumbyamytilusedulisderivedosteogenicpeptide
AT duming characterizationofchelationandabsorptionofcalciumbyamytilusedulisderivedosteogenicpeptide
AT litingting characterizationofchelationandabsorptionofcalciumbyamytilusedulisderivedosteogenicpeptide

Ejemplares similares