Lung function, airway and peripheral basophils and eosinophils are associated with molecular pharmacogenomic endotypes of steroid response in severe asthma

INTRODUCTION: Asthma is a complex disease with heterogeneous expression/severity. There is growing interest in defining asthma endotypes consistently associated with different responses to therapy, focusing on type 2 inflammation (Th2) as a key pathological mechanism. Current asthma endotypes are de...

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Detalles Bibliográficos
Autores principales: Kho, Alvin T, McGeachie, Michael J, Li, Jiang, Chase, Robert P, Amr, Sami S, Hastie, Annette T, Hawkins, Gregory A, Li, Xingnan, Chupp, Geoffrey L, Meyers, Deborah A, Bleecker, Eugene R, Weiss, Scott T, Tantisira, Kelan G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Asthma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016241/
https://www.ncbi.nlm.nih.gov/pubmed/34580195
http://dx.doi.org/10.1136/thoraxjnl-2020-215523

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