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Functional Specialization of the Medial Temporal Lobes in Human Recognition Memory: Dissociating Effects of Hippocampal versus Parahippocampal Damage
A central debate in the systems neuroscience of memory concerns whether different medial temporal lobe (MTL) structures support different processes in recognition memory. Using two recognition memory paradigms, we tested a rare patient (MH) with a perirhinal lesion that appeared to spare the hippoca...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016283/ https://www.ncbi.nlm.nih.gov/pubmed/34535797 http://dx.doi.org/10.1093/cercor/bhab290 |
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author | Argyropoulos, Georgios P D Dell’Acqua, Carola Butler, Emily Loane, Clare Roca-Fernandez, Adriana Almozel, Azhaar Drummond, Nikolas Lage-Martinez, Carmen Cooper, Elisa Henson, Richard N Butler, Christopher R |
author_facet | Argyropoulos, Georgios P D Dell’Acqua, Carola Butler, Emily Loane, Clare Roca-Fernandez, Adriana Almozel, Azhaar Drummond, Nikolas Lage-Martinez, Carmen Cooper, Elisa Henson, Richard N Butler, Christopher R |
author_sort | Argyropoulos, Georgios P D |
collection | PubMed |
description | A central debate in the systems neuroscience of memory concerns whether different medial temporal lobe (MTL) structures support different processes in recognition memory. Using two recognition memory paradigms, we tested a rare patient (MH) with a perirhinal lesion that appeared to spare the hippocampus. Consistent with a similar previous case, MH showed impaired familiarity and preserved recollection. When compared with patients with hippocampal lesions appearing to spare perirhinal cortex, MH showed greater impairment on familiarity and less on recollection. Nevertheless, the hippocampal patients also showed impaired familiarity compared with healthy controls. However, when replacing this traditional categorization of patients with analyses relating memory performance to continuous measures of damage across patients, hippocampal volume uniquely predicted recollection, whereas parahippocampal, rather than perirhinal, volume uniquely predicted familiarity. We consider whether the familiarity impairment in MH and our patients with hippocampal lesions arises from “subthreshold” damage to parahippocampal cortex (PHC). Our data provide the most compelling neuropsychological support yet for dual-process models of recognition memory, whereby recollection and familiarity depend on different MTL structures, and may support a role for PHC in familiarity. Our study highlights the value of supplementing single-case studies with examinations of continuous brain–behavior relationships across larger patient groups. |
format | Online Article Text |
id | pubmed-9016283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-90162832022-04-20 Functional Specialization of the Medial Temporal Lobes in Human Recognition Memory: Dissociating Effects of Hippocampal versus Parahippocampal Damage Argyropoulos, Georgios P D Dell’Acqua, Carola Butler, Emily Loane, Clare Roca-Fernandez, Adriana Almozel, Azhaar Drummond, Nikolas Lage-Martinez, Carmen Cooper, Elisa Henson, Richard N Butler, Christopher R Cereb Cortex Original Article A central debate in the systems neuroscience of memory concerns whether different medial temporal lobe (MTL) structures support different processes in recognition memory. Using two recognition memory paradigms, we tested a rare patient (MH) with a perirhinal lesion that appeared to spare the hippocampus. Consistent with a similar previous case, MH showed impaired familiarity and preserved recollection. When compared with patients with hippocampal lesions appearing to spare perirhinal cortex, MH showed greater impairment on familiarity and less on recollection. Nevertheless, the hippocampal patients also showed impaired familiarity compared with healthy controls. However, when replacing this traditional categorization of patients with analyses relating memory performance to continuous measures of damage across patients, hippocampal volume uniquely predicted recollection, whereas parahippocampal, rather than perirhinal, volume uniquely predicted familiarity. We consider whether the familiarity impairment in MH and our patients with hippocampal lesions arises from “subthreshold” damage to parahippocampal cortex (PHC). Our data provide the most compelling neuropsychological support yet for dual-process models of recognition memory, whereby recollection and familiarity depend on different MTL structures, and may support a role for PHC in familiarity. Our study highlights the value of supplementing single-case studies with examinations of continuous brain–behavior relationships across larger patient groups. Oxford University Press 2021-09-17 /pmc/articles/PMC9016283/ /pubmed/34535797 http://dx.doi.org/10.1093/cercor/bhab290 Text en © The Author(s) 2021. Published by Oxford University Press https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Argyropoulos, Georgios P D Dell’Acqua, Carola Butler, Emily Loane, Clare Roca-Fernandez, Adriana Almozel, Azhaar Drummond, Nikolas Lage-Martinez, Carmen Cooper, Elisa Henson, Richard N Butler, Christopher R Functional Specialization of the Medial Temporal Lobes in Human Recognition Memory: Dissociating Effects of Hippocampal versus Parahippocampal Damage |
title | Functional Specialization of the Medial Temporal Lobes in Human Recognition Memory: Dissociating Effects of Hippocampal versus Parahippocampal Damage |
title_full | Functional Specialization of the Medial Temporal Lobes in Human Recognition Memory: Dissociating Effects of Hippocampal versus Parahippocampal Damage |
title_fullStr | Functional Specialization of the Medial Temporal Lobes in Human Recognition Memory: Dissociating Effects of Hippocampal versus Parahippocampal Damage |
title_full_unstemmed | Functional Specialization of the Medial Temporal Lobes in Human Recognition Memory: Dissociating Effects of Hippocampal versus Parahippocampal Damage |
title_short | Functional Specialization of the Medial Temporal Lobes in Human Recognition Memory: Dissociating Effects of Hippocampal versus Parahippocampal Damage |
title_sort | functional specialization of the medial temporal lobes in human recognition memory: dissociating effects of hippocampal versus parahippocampal damage |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016283/ https://www.ncbi.nlm.nih.gov/pubmed/34535797 http://dx.doi.org/10.1093/cercor/bhab290 |
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