HOIL‐1 ubiquitin ligase activity targets unbranched glucosaccharides and is required to prevent polyglucosan accumulation

HOIL‐1, a component of the linear ubiquitin chain assembly complex (LUBAC), ubiquitylates serine and threonine residues in proteins by esterification. Here, we report that mice expressing an E3 ligase‐inactive HOIL‐1[C458S] mutant accumulate polyglucosan in brain, heart and other organs, indicating...

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Detalles Bibliográficos
Autores principales: Kelsall, Ian R, McCrory, Elisha H, Xu, Yingqi, Scudamore, Cheryl L, Nanda, Sambit K, Mancebo‐Gamella, Paula, Wood, Nicola T, Knebel, Axel, Matthews, Stephen J, Cohen, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016349/
https://www.ncbi.nlm.nih.gov/pubmed/35274759
http://dx.doi.org/10.15252/embj.2021109700

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