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ADAM17 Mediates Proteolytic Maturation of Voltage-Gated Calcium Channel Auxiliary α(2)δ Subunits, and Enables Calcium Current Enhancement

The auxiliary α(2)δ subunits of voltage-gated calcium (Ca(V)) channels are key to augmenting expression and function of Ca(V)1 and Ca(V)2 channels, and are also important drug targets in several therapeutic areas, including neuropathic pain. The α(2)δ proteins are translated as preproteins encoding...

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Detalles Bibliográficos
Autores principales:	Kadurin, Ivan, Dahimene, Shehrazade, Page, Karen M, Ellaway, Joseph I J, Chaggar, Kanchan, Troeberg, Linda, Nagase, Hideaki, Dolphin, Annette C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016415/ https://www.ncbi.nlm.nih.gov/pubmed/35462614 http://dx.doi.org/10.1093/function/zqac013

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