Cargando…
Incidence of Cardiometabolic Diseases in People With and Without Human Immunodeficiency Virus in the United Kingdom: A Population-Based Matched Cohort Study
BACKGROUND: Evidence on the risk of cardiovascular disease (CVD) and CVD risk factors in people with human immunodeficiency virus (PWH) is limited. We aimed to identify the risk of composite CVD, individual CVD events, and common risk factors. METHODS: This was a nationwide, population-based, cohort...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016421/ https://www.ncbi.nlm.nih.gov/pubmed/34417792 http://dx.doi.org/10.1093/infdis/jiab420 |
_version_ | 1784688526563999744 |
---|---|
author | Gooden, Tiffany E Gardner, Mike Wang, Jingya Jolly, Kate Lane, Deirdre A Benjamin, Laura A Mwandumba, Henry C Kandoole, Vanessa Lwanga, Isaac B Taylor, Stephen Manaseki-Holland, Semira Lip, Gregory Y H Nirantharakumar, Krishnarajah Thomas, G Neil |
author_facet | Gooden, Tiffany E Gardner, Mike Wang, Jingya Jolly, Kate Lane, Deirdre A Benjamin, Laura A Mwandumba, Henry C Kandoole, Vanessa Lwanga, Isaac B Taylor, Stephen Manaseki-Holland, Semira Lip, Gregory Y H Nirantharakumar, Krishnarajah Thomas, G Neil |
author_sort | Gooden, Tiffany E |
collection | PubMed |
description | BACKGROUND: Evidence on the risk of cardiovascular disease (CVD) and CVD risk factors in people with human immunodeficiency virus (PWH) is limited. We aimed to identify the risk of composite CVD, individual CVD events, and common risk factors. METHODS: This was a nationwide, population-based, cohort study comparing adult (≥18 years old) PWH with people without human immunodeficiency virus (HIV) matched on age, sex, ethnicity, and location. The primary outcome was composite CVD comprising stroke, myocardial infarction, peripheral vascular disease, ischemic heart disease, and heart failure. The secondary outcomes were individual CVD events, hypertension, diabetes, chronic kidney disease (CKD), and all-cause mortality. Cox proportional hazard regression models were used to examine the risk of each outcome. RESULTS: We identified 9233 PWH and matched them with 35 721 HIV-negative individuals. An increased risk was found for composite CVD (adjusted hazard ratio [aHR], 1.50; 95% confidence interval [CI], 1.28–1.77), stroke (aHR, 1.42; 95% CI, 1.08–1.86), ischemic heart disease (aHR, 1.55; 95% CI, 1.24–1.94), hypertension (aHR, 1.37; 95% CI, 1.23–1.53), type 2 diabetes (aHR, 1.28; 95% CI, 1.09–1.50), CKD (aHR, 2.42; 95% CI, 1.98–2.94), and all-cause mortality (aHR, 2.84; 95% CI, 2.48–3.25). CONCLUSIONS: PWH have a heightened risk for CVD and common CVD risk factors, reinforcing the importance for regular screening for such conditions. |
format | Online Article Text |
id | pubmed-9016421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-90164212022-04-20 Incidence of Cardiometabolic Diseases in People With and Without Human Immunodeficiency Virus in the United Kingdom: A Population-Based Matched Cohort Study Gooden, Tiffany E Gardner, Mike Wang, Jingya Jolly, Kate Lane, Deirdre A Benjamin, Laura A Mwandumba, Henry C Kandoole, Vanessa Lwanga, Isaac B Taylor, Stephen Manaseki-Holland, Semira Lip, Gregory Y H Nirantharakumar, Krishnarajah Thomas, G Neil J Infect Dis Major Articles and Brief Reports BACKGROUND: Evidence on the risk of cardiovascular disease (CVD) and CVD risk factors in people with human immunodeficiency virus (PWH) is limited. We aimed to identify the risk of composite CVD, individual CVD events, and common risk factors. METHODS: This was a nationwide, population-based, cohort study comparing adult (≥18 years old) PWH with people without human immunodeficiency virus (HIV) matched on age, sex, ethnicity, and location. The primary outcome was composite CVD comprising stroke, myocardial infarction, peripheral vascular disease, ischemic heart disease, and heart failure. The secondary outcomes were individual CVD events, hypertension, diabetes, chronic kidney disease (CKD), and all-cause mortality. Cox proportional hazard regression models were used to examine the risk of each outcome. RESULTS: We identified 9233 PWH and matched them with 35 721 HIV-negative individuals. An increased risk was found for composite CVD (adjusted hazard ratio [aHR], 1.50; 95% confidence interval [CI], 1.28–1.77), stroke (aHR, 1.42; 95% CI, 1.08–1.86), ischemic heart disease (aHR, 1.55; 95% CI, 1.24–1.94), hypertension (aHR, 1.37; 95% CI, 1.23–1.53), type 2 diabetes (aHR, 1.28; 95% CI, 1.09–1.50), CKD (aHR, 2.42; 95% CI, 1.98–2.94), and all-cause mortality (aHR, 2.84; 95% CI, 2.48–3.25). CONCLUSIONS: PWH have a heightened risk for CVD and common CVD risk factors, reinforcing the importance for regular screening for such conditions. Oxford University Press 2021-08-21 /pmc/articles/PMC9016421/ /pubmed/34417792 http://dx.doi.org/10.1093/infdis/jiab420 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Major Articles and Brief Reports Gooden, Tiffany E Gardner, Mike Wang, Jingya Jolly, Kate Lane, Deirdre A Benjamin, Laura A Mwandumba, Henry C Kandoole, Vanessa Lwanga, Isaac B Taylor, Stephen Manaseki-Holland, Semira Lip, Gregory Y H Nirantharakumar, Krishnarajah Thomas, G Neil Incidence of Cardiometabolic Diseases in People With and Without Human Immunodeficiency Virus in the United Kingdom: A Population-Based Matched Cohort Study |
title | Incidence of Cardiometabolic Diseases in People With and Without Human Immunodeficiency Virus in the United Kingdom: A Population-Based Matched Cohort Study |
title_full | Incidence of Cardiometabolic Diseases in People With and Without Human Immunodeficiency Virus in the United Kingdom: A Population-Based Matched Cohort Study |
title_fullStr | Incidence of Cardiometabolic Diseases in People With and Without Human Immunodeficiency Virus in the United Kingdom: A Population-Based Matched Cohort Study |
title_full_unstemmed | Incidence of Cardiometabolic Diseases in People With and Without Human Immunodeficiency Virus in the United Kingdom: A Population-Based Matched Cohort Study |
title_short | Incidence of Cardiometabolic Diseases in People With and Without Human Immunodeficiency Virus in the United Kingdom: A Population-Based Matched Cohort Study |
title_sort | incidence of cardiometabolic diseases in people with and without human immunodeficiency virus in the united kingdom: a population-based matched cohort study |
topic | Major Articles and Brief Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016421/ https://www.ncbi.nlm.nih.gov/pubmed/34417792 http://dx.doi.org/10.1093/infdis/jiab420 |
work_keys_str_mv | AT goodentiffanye incidenceofcardiometabolicdiseasesinpeoplewithandwithouthumanimmunodeficiencyvirusintheunitedkingdomapopulationbasedmatchedcohortstudy AT gardnermike incidenceofcardiometabolicdiseasesinpeoplewithandwithouthumanimmunodeficiencyvirusintheunitedkingdomapopulationbasedmatchedcohortstudy AT wangjingya incidenceofcardiometabolicdiseasesinpeoplewithandwithouthumanimmunodeficiencyvirusintheunitedkingdomapopulationbasedmatchedcohortstudy AT jollykate incidenceofcardiometabolicdiseasesinpeoplewithandwithouthumanimmunodeficiencyvirusintheunitedkingdomapopulationbasedmatchedcohortstudy AT lanedeirdrea incidenceofcardiometabolicdiseasesinpeoplewithandwithouthumanimmunodeficiencyvirusintheunitedkingdomapopulationbasedmatchedcohortstudy AT benjaminlauraa incidenceofcardiometabolicdiseasesinpeoplewithandwithouthumanimmunodeficiencyvirusintheunitedkingdomapopulationbasedmatchedcohortstudy AT mwandumbahenryc incidenceofcardiometabolicdiseasesinpeoplewithandwithouthumanimmunodeficiencyvirusintheunitedkingdomapopulationbasedmatchedcohortstudy AT kandoolevanessa incidenceofcardiometabolicdiseasesinpeoplewithandwithouthumanimmunodeficiencyvirusintheunitedkingdomapopulationbasedmatchedcohortstudy AT lwangaisaacb incidenceofcardiometabolicdiseasesinpeoplewithandwithouthumanimmunodeficiencyvirusintheunitedkingdomapopulationbasedmatchedcohortstudy AT taylorstephen incidenceofcardiometabolicdiseasesinpeoplewithandwithouthumanimmunodeficiencyvirusintheunitedkingdomapopulationbasedmatchedcohortstudy AT manasekihollandsemira incidenceofcardiometabolicdiseasesinpeoplewithandwithouthumanimmunodeficiencyvirusintheunitedkingdomapopulationbasedmatchedcohortstudy AT lipgregoryyh incidenceofcardiometabolicdiseasesinpeoplewithandwithouthumanimmunodeficiencyvirusintheunitedkingdomapopulationbasedmatchedcohortstudy AT nirantharakumarkrishnarajah incidenceofcardiometabolicdiseasesinpeoplewithandwithouthumanimmunodeficiencyvirusintheunitedkingdomapopulationbasedmatchedcohortstudy AT thomasgneil incidenceofcardiometabolicdiseasesinpeoplewithandwithouthumanimmunodeficiencyvirusintheunitedkingdomapopulationbasedmatchedcohortstudy |