Clonal Hematopoiesis Is Associated With Low CD4 Nadir and Increased Residual HIV Transcriptional Activity in Virally Suppressed Individuals With HIV

Clonal hematopoiesis, a common age-related phenomenon marked by expansion of cells with clonal hematopoiesis driver mutations, has been associated with all-cause mortality, cancer, and cardiovascular disease. People with HIV (PWH) are at risk for non-AIDS–related comorbidities such as atheroscleroti...

Descripción completa

Detalles Bibliográficos
Autores principales: van der Heijden, Wouter A, van Deuren, Rosanne C, van de Wijer, Lisa, van den Munckhof, Inge C L, Steehouwer, Marloes, Riksen, Niels P, Netea, Mihai G, de Mast, Quirijn, Vandekerckhove, Linos, de Voer, Richarda M, van der Ven, Andre J, Hoischen, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016425/
https://www.ncbi.nlm.nih.gov/pubmed/34417800
http://dx.doi.org/10.1093/infdis/jiab419
_version_ 1784688527552806912
author van der Heijden, Wouter A
van Deuren, Rosanne C
van de Wijer, Lisa
van den Munckhof, Inge C L
Steehouwer, Marloes
Riksen, Niels P
Netea, Mihai G
de Mast, Quirijn
Vandekerckhove, Linos
de Voer, Richarda M
van der Ven, Andre J
Hoischen, Alexander
author_facet van der Heijden, Wouter A
van Deuren, Rosanne C
van de Wijer, Lisa
van den Munckhof, Inge C L
Steehouwer, Marloes
Riksen, Niels P
Netea, Mihai G
de Mast, Quirijn
Vandekerckhove, Linos
de Voer, Richarda M
van der Ven, Andre J
Hoischen, Alexander
author_sort van der Heijden, Wouter A
collection PubMed
description Clonal hematopoiesis, a common age-related phenomenon marked by expansion of cells with clonal hematopoiesis driver mutations, has been associated with all-cause mortality, cancer, and cardiovascular disease. People with HIV (PWH) are at risk for non-AIDS–related comorbidities such as atherosclerotic cardiovascular disease and cancer. In a cross-sectional cohort study, we compared clonal hematopoiesis prevalence in PWH on stable antiretroviral therapy with prevalence in a cohort of overweight individuals and a cohort of age- and sex-matched population controls. The prevalence of clonal hematopoiesis adjusted for age was increased and clone size was larger in PWH compared to population controls. Clonal hematopoiesis is associated with low CD4 nadir, increased residual HIV-1 transcriptional activity, and coagulation factors in PWH. Future studies on the effect of clonal hematopoiesis on the HIV reservoir and non-AIDS–related comorbidities are warranted.
format Online
Article
Text
id pubmed-9016425
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-90164252022-04-20 Clonal Hematopoiesis Is Associated With Low CD4 Nadir and Increased Residual HIV Transcriptional Activity in Virally Suppressed Individuals With HIV van der Heijden, Wouter A van Deuren, Rosanne C van de Wijer, Lisa van den Munckhof, Inge C L Steehouwer, Marloes Riksen, Niels P Netea, Mihai G de Mast, Quirijn Vandekerckhove, Linos de Voer, Richarda M van der Ven, Andre J Hoischen, Alexander J Infect Dis Major Articles and Brief Reports Clonal hematopoiesis, a common age-related phenomenon marked by expansion of cells with clonal hematopoiesis driver mutations, has been associated with all-cause mortality, cancer, and cardiovascular disease. People with HIV (PWH) are at risk for non-AIDS–related comorbidities such as atherosclerotic cardiovascular disease and cancer. In a cross-sectional cohort study, we compared clonal hematopoiesis prevalence in PWH on stable antiretroviral therapy with prevalence in a cohort of overweight individuals and a cohort of age- and sex-matched population controls. The prevalence of clonal hematopoiesis adjusted for age was increased and clone size was larger in PWH compared to population controls. Clonal hematopoiesis is associated with low CD4 nadir, increased residual HIV-1 transcriptional activity, and coagulation factors in PWH. Future studies on the effect of clonal hematopoiesis on the HIV reservoir and non-AIDS–related comorbidities are warranted. Oxford University Press 2021-08-21 /pmc/articles/PMC9016425/ /pubmed/34417800 http://dx.doi.org/10.1093/infdis/jiab419 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Major Articles and Brief Reports
van der Heijden, Wouter A
van Deuren, Rosanne C
van de Wijer, Lisa
van den Munckhof, Inge C L
Steehouwer, Marloes
Riksen, Niels P
Netea, Mihai G
de Mast, Quirijn
Vandekerckhove, Linos
de Voer, Richarda M
van der Ven, Andre J
Hoischen, Alexander
Clonal Hematopoiesis Is Associated With Low CD4 Nadir and Increased Residual HIV Transcriptional Activity in Virally Suppressed Individuals With HIV
title Clonal Hematopoiesis Is Associated With Low CD4 Nadir and Increased Residual HIV Transcriptional Activity in Virally Suppressed Individuals With HIV
title_full Clonal Hematopoiesis Is Associated With Low CD4 Nadir and Increased Residual HIV Transcriptional Activity in Virally Suppressed Individuals With HIV
title_fullStr Clonal Hematopoiesis Is Associated With Low CD4 Nadir and Increased Residual HIV Transcriptional Activity in Virally Suppressed Individuals With HIV
title_full_unstemmed Clonal Hematopoiesis Is Associated With Low CD4 Nadir and Increased Residual HIV Transcriptional Activity in Virally Suppressed Individuals With HIV
title_short Clonal Hematopoiesis Is Associated With Low CD4 Nadir and Increased Residual HIV Transcriptional Activity in Virally Suppressed Individuals With HIV
title_sort clonal hematopoiesis is associated with low cd4 nadir and increased residual hiv transcriptional activity in virally suppressed individuals with hiv
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016425/
https://www.ncbi.nlm.nih.gov/pubmed/34417800
http://dx.doi.org/10.1093/infdis/jiab419
work_keys_str_mv AT vanderheijdenwoutera clonalhematopoiesisisassociatedwithlowcd4nadirandincreasedresidualhivtranscriptionalactivityinvirallysuppressedindividualswithhiv
AT vandeurenrosannec clonalhematopoiesisisassociatedwithlowcd4nadirandincreasedresidualhivtranscriptionalactivityinvirallysuppressedindividualswithhiv
AT vandewijerlisa clonalhematopoiesisisassociatedwithlowcd4nadirandincreasedresidualhivtranscriptionalactivityinvirallysuppressedindividualswithhiv
AT vandenmunckhofingecl clonalhematopoiesisisassociatedwithlowcd4nadirandincreasedresidualhivtranscriptionalactivityinvirallysuppressedindividualswithhiv
AT steehouwermarloes clonalhematopoiesisisassociatedwithlowcd4nadirandincreasedresidualhivtranscriptionalactivityinvirallysuppressedindividualswithhiv
AT riksennielsp clonalhematopoiesisisassociatedwithlowcd4nadirandincreasedresidualhivtranscriptionalactivityinvirallysuppressedindividualswithhiv
AT neteamihaig clonalhematopoiesisisassociatedwithlowcd4nadirandincreasedresidualhivtranscriptionalactivityinvirallysuppressedindividualswithhiv
AT demastquirijn clonalhematopoiesisisassociatedwithlowcd4nadirandincreasedresidualhivtranscriptionalactivityinvirallysuppressedindividualswithhiv
AT vandekerckhovelinos clonalhematopoiesisisassociatedwithlowcd4nadirandincreasedresidualhivtranscriptionalactivityinvirallysuppressedindividualswithhiv
AT devoerrichardam clonalhematopoiesisisassociatedwithlowcd4nadirandincreasedresidualhivtranscriptionalactivityinvirallysuppressedindividualswithhiv
AT vandervenandrej clonalhematopoiesisisassociatedwithlowcd4nadirandincreasedresidualhivtranscriptionalactivityinvirallysuppressedindividualswithhiv
AT hoischenalexander clonalhematopoiesisisassociatedwithlowcd4nadirandincreasedresidualhivtranscriptionalactivityinvirallysuppressedindividualswithhiv

Ejemplares similares