Sintilimab versus placebo in combination with chemotherapy as first line treatment for locally advanced or metastatic oesophageal squamous cell carcinoma (ORIENT-15): multicentre, randomised, double blind, phase 3 trial

OBJECTIVE: To evaluate sintilimab versus placebo in combination with chemotherapy (cisplatin plus paclitaxel or cisplatin plus 5-fluorouracil) as first line treatment of unresectable locally advanced, recurrent, or metastatic oesophageal squamous cell carcinoma. DESIGN: Multicentre, randomised, doub...

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Detalles Bibliográficos
Autores principales: Lu, Zhihao, Wang, Junye, Shu, Yongqian, Liu, Lianke, Kong, Li, Yang, Lei, Wang, Buhai, Sun, Guogui, Ji, Yinghua, Cao, Guochun, Liu, Hu, Cui, Tongjian, Li, Na, Qiu, Wensheng, Li, Gaofeng, Hou, Xinfang, Luo, Hui, Xue, Liying, Zhang, Yanqiao, Yue, Wenbin, Liu, Zheng, Wang, Xiuwen, Gao, Shegan, Pan, Yueyin, Galais, Marie-Pierre, Zaanan, Aziz, Ma, Zhuo, Li, Haoyu, Wang, Yan, Shen, Lin, Pan, Zhanyu, Zhang, Shuqun, Lin, Gen, Xie, Yanru, Li, Tao, Ren, Tiejun, Li, Weidong, Gu, Kangsheng, Wang, Shoufeng, He, Wei, Xia, Bing, Fan, Yun, Liang, Jun, Zhao, Kuaile, Pan, Hongming, Xu, Nong, Cheng, Ying, Gao, Quanli, Sun, Ping, Zang, Aimin, Zheng, Anping, Luo, Zhiguo, Liu, Tianshu, Ding, Shubo, Xu, Tianwen, Li, Wei, Liu, Fang, Cang, Shundong, Wang, Junsheng, Lin, Xiaoyan, Jiang, Da, Mao, Rui, Ma, Dong, Liu, Yunpeng, Tao, Min, Tang, Yong, Chen, Xi, Chen, Ping, Feng, Guosheng, Yang, Zhenzhou, Zhang, Guifang, Zhang, Xuebang, Huang, Yong, Lee, Fa-Chyi, Dean, Andrew, El Hajbi, Farid, Ghiringhelli, François, Borg, Christophe, Tougeron, David, Dahan, Laetitia, Pernot, Simon, Rivera, Fernando, Pazo Cid, Roberto Antonio, Vazquez Rivera, Maria Francisca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group Ltd. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016493/
https://www.ncbi.nlm.nih.gov/pubmed/35440464
http://dx.doi.org/10.1136/bmj-2021-068714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016493/
https://www.ncbi.nlm.nih.gov/pubmed/35440464
http://dx.doi.org/10.1136/bmj-2021-068714

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