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Quality of Life of Prostate Cancer Survivors Participating in a Remotely Delivered Web-Based Behavioral Intervention Pilot Randomized Trial
BACKGROUND: Following a prostate cancer (PC) diagnosis, treatment-related symptoms may result in diminished quality of life (QoL). Improved diet and increased exercise may improve QoL in men with PC. METHODS: We conducted a 4-arm pilot randomized trial to assess feasibility and acceptability of a 3-...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016550/ https://www.ncbi.nlm.nih.gov/pubmed/35389288 http://dx.doi.org/10.1177/15347354211063500 |
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author | Langlais, Crystal S. Chen, Yea-Hung Van Blarigan, Erin L. Kenfield, Stacey A. Kessler, Elizabeth R. Daniel, Kimi Ramsdill, Justin W. Beer, Tomasz M. Graff, Rebecca E. Paich, Kellie Chan, June M. Winters-Stone, Kerri M. |
author_facet | Langlais, Crystal S. Chen, Yea-Hung Van Blarigan, Erin L. Kenfield, Stacey A. Kessler, Elizabeth R. Daniel, Kimi Ramsdill, Justin W. Beer, Tomasz M. Graff, Rebecca E. Paich, Kellie Chan, June M. Winters-Stone, Kerri M. |
author_sort | Langlais, Crystal S. |
collection | PubMed |
description | BACKGROUND: Following a prostate cancer (PC) diagnosis, treatment-related symptoms may result in diminished quality of life (QoL). Improved diet and increased exercise may improve QoL in men with PC. METHODS: We conducted a 4-arm pilot randomized trial to assess feasibility and acceptability of a 3-month web-based diet and exercise intervention, among men (>18 years of age) with PC (reported elsewhere). The purpose of this study is to describe the change in QoL measured by surveys (eg, QLQ-C30, PROMIS Fatigue) at enrollment and following the intervention. Men were randomized 1:1:1:1 to increasing levels of web-based behavioral support: Level 1: website; Level 2: Level 1 plus personalized diet and exercise prescription; Level 3: Levels 1-2 plus Fitbit and text messages; Level 4: Levels 1-3 plus 2 30-minute coaching calls. T-tests were used to compare pre-post change in mean QoL scores between each Level and Level 1. RESULTS: Two hundred and two men consented and were randomized (n = 49, 51, 50, 52 for Levels 1-4, respectively). Men were predominantly white (93%), with a median age of 70 years (Intra-quartile Range [IQR]: 65,75) and 3 years (IQR: 1,9) post primary treatment for mostly localized disease (74% with T1-2). There were no meaningful changes in QoL, but there were notable trends. Level 3 participants had small improvements in QLQ-C30 Global Health (5.46; 95% CI: −0.02, 10.95) compared to Level 1. In contrast, Level 2 participants trended toward decreasing Global QoL (−2.31, 95% CI: −8.05, 3.42), which may reflect declines in function (eg, Cognitive: −6.94, 95% CI: −13.76, −0.13) and higher symptom burden (eg, Diarrhea: 4.63, 95% CI: −1.48, 10.74). CONCLUSIONS: This short, web-based intervention did not appear to have an impact on PC survivors’ QoL. Most men were several years past treatment for localized disease; the potential for this approach to reduce symptoms and improve QoL in men who have worse health may still be warranted. |
format | Online Article Text |
id | pubmed-9016550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-90165502022-04-20 Quality of Life of Prostate Cancer Survivors Participating in a Remotely Delivered Web-Based Behavioral Intervention Pilot Randomized Trial Langlais, Crystal S. Chen, Yea-Hung Van Blarigan, Erin L. Kenfield, Stacey A. Kessler, Elizabeth R. Daniel, Kimi Ramsdill, Justin W. Beer, Tomasz M. Graff, Rebecca E. Paich, Kellie Chan, June M. Winters-Stone, Kerri M. Integr Cancer Ther Research Article BACKGROUND: Following a prostate cancer (PC) diagnosis, treatment-related symptoms may result in diminished quality of life (QoL). Improved diet and increased exercise may improve QoL in men with PC. METHODS: We conducted a 4-arm pilot randomized trial to assess feasibility and acceptability of a 3-month web-based diet and exercise intervention, among men (>18 years of age) with PC (reported elsewhere). The purpose of this study is to describe the change in QoL measured by surveys (eg, QLQ-C30, PROMIS Fatigue) at enrollment and following the intervention. Men were randomized 1:1:1:1 to increasing levels of web-based behavioral support: Level 1: website; Level 2: Level 1 plus personalized diet and exercise prescription; Level 3: Levels 1-2 plus Fitbit and text messages; Level 4: Levels 1-3 plus 2 30-minute coaching calls. T-tests were used to compare pre-post change in mean QoL scores between each Level and Level 1. RESULTS: Two hundred and two men consented and were randomized (n = 49, 51, 50, 52 for Levels 1-4, respectively). Men were predominantly white (93%), with a median age of 70 years (Intra-quartile Range [IQR]: 65,75) and 3 years (IQR: 1,9) post primary treatment for mostly localized disease (74% with T1-2). There were no meaningful changes in QoL, but there were notable trends. Level 3 participants had small improvements in QLQ-C30 Global Health (5.46; 95% CI: −0.02, 10.95) compared to Level 1. In contrast, Level 2 participants trended toward decreasing Global QoL (−2.31, 95% CI: −8.05, 3.42), which may reflect declines in function (eg, Cognitive: −6.94, 95% CI: −13.76, −0.13) and higher symptom burden (eg, Diarrhea: 4.63, 95% CI: −1.48, 10.74). CONCLUSIONS: This short, web-based intervention did not appear to have an impact on PC survivors’ QoL. Most men were several years past treatment for localized disease; the potential for this approach to reduce symptoms and improve QoL in men who have worse health may still be warranted. SAGE Publications 2022-04-07 /pmc/articles/PMC9016550/ /pubmed/35389288 http://dx.doi.org/10.1177/15347354211063500 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Research Article Langlais, Crystal S. Chen, Yea-Hung Van Blarigan, Erin L. Kenfield, Stacey A. Kessler, Elizabeth R. Daniel, Kimi Ramsdill, Justin W. Beer, Tomasz M. Graff, Rebecca E. Paich, Kellie Chan, June M. Winters-Stone, Kerri M. Quality of Life of Prostate Cancer Survivors Participating in a Remotely Delivered Web-Based Behavioral Intervention Pilot Randomized Trial |
title | Quality of Life of Prostate Cancer Survivors Participating in a
Remotely Delivered Web-Based Behavioral Intervention Pilot Randomized
Trial |
title_full | Quality of Life of Prostate Cancer Survivors Participating in a
Remotely Delivered Web-Based Behavioral Intervention Pilot Randomized
Trial |
title_fullStr | Quality of Life of Prostate Cancer Survivors Participating in a
Remotely Delivered Web-Based Behavioral Intervention Pilot Randomized
Trial |
title_full_unstemmed | Quality of Life of Prostate Cancer Survivors Participating in a
Remotely Delivered Web-Based Behavioral Intervention Pilot Randomized
Trial |
title_short | Quality of Life of Prostate Cancer Survivors Participating in a
Remotely Delivered Web-Based Behavioral Intervention Pilot Randomized
Trial |
title_sort | quality of life of prostate cancer survivors participating in a
remotely delivered web-based behavioral intervention pilot randomized
trial |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016550/ https://www.ncbi.nlm.nih.gov/pubmed/35389288 http://dx.doi.org/10.1177/15347354211063500 |
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