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Quality of Life of Prostate Cancer Survivors Participating in a Remotely Delivered Web-Based Behavioral Intervention Pilot Randomized Trial

BACKGROUND: Following a prostate cancer (PC) diagnosis, treatment-related symptoms may result in diminished quality of life (QoL). Improved diet and increased exercise may improve QoL in men with PC. METHODS: We conducted a 4-arm pilot randomized trial to assess feasibility and acceptability of a 3-...

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Autores principales: Langlais, Crystal S., Chen, Yea-Hung, Van Blarigan, Erin L., Kenfield, Stacey A., Kessler, Elizabeth R., Daniel, Kimi, Ramsdill, Justin W., Beer, Tomasz M., Graff, Rebecca E., Paich, Kellie, Chan, June M., Winters-Stone, Kerri M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016550/
https://www.ncbi.nlm.nih.gov/pubmed/35389288
http://dx.doi.org/10.1177/15347354211063500
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author Langlais, Crystal S.
Chen, Yea-Hung
Van Blarigan, Erin L.
Kenfield, Stacey A.
Kessler, Elizabeth R.
Daniel, Kimi
Ramsdill, Justin W.
Beer, Tomasz M.
Graff, Rebecca E.
Paich, Kellie
Chan, June M.
Winters-Stone, Kerri M.
author_facet Langlais, Crystal S.
Chen, Yea-Hung
Van Blarigan, Erin L.
Kenfield, Stacey A.
Kessler, Elizabeth R.
Daniel, Kimi
Ramsdill, Justin W.
Beer, Tomasz M.
Graff, Rebecca E.
Paich, Kellie
Chan, June M.
Winters-Stone, Kerri M.
author_sort Langlais, Crystal S.
collection PubMed
description BACKGROUND: Following a prostate cancer (PC) diagnosis, treatment-related symptoms may result in diminished quality of life (QoL). Improved diet and increased exercise may improve QoL in men with PC. METHODS: We conducted a 4-arm pilot randomized trial to assess feasibility and acceptability of a 3-month web-based diet and exercise intervention, among men (>18 years of age) with PC (reported elsewhere). The purpose of this study is to describe the change in QoL measured by surveys (eg, QLQ-C30, PROMIS Fatigue) at enrollment and following the intervention. Men were randomized 1:1:1:1 to increasing levels of web-based behavioral support: Level 1: website; Level 2: Level 1 plus personalized diet and exercise prescription; Level 3: Levels 1-2 plus Fitbit and text messages; Level 4: Levels 1-3 plus 2 30-minute coaching calls. T-tests were used to compare pre-post change in mean QoL scores between each Level and Level 1. RESULTS: Two hundred and two men consented and were randomized (n = 49, 51, 50, 52 for Levels 1-4, respectively). Men were predominantly white (93%), with a median age of 70 years (Intra-quartile Range [IQR]: 65,75) and 3 years (IQR: 1,9) post primary treatment for mostly localized disease (74% with T1-2). There were no meaningful changes in QoL, but there were notable trends. Level 3 participants had small improvements in QLQ-C30 Global Health (5.46; 95% CI: −0.02, 10.95) compared to Level 1. In contrast, Level 2 participants trended toward decreasing Global QoL (−2.31, 95% CI: −8.05, 3.42), which may reflect declines in function (eg, Cognitive: −6.94, 95% CI: −13.76, −0.13) and higher symptom burden (eg, Diarrhea: 4.63, 95% CI: −1.48, 10.74). CONCLUSIONS: This short, web-based intervention did not appear to have an impact on PC survivors’ QoL. Most men were several years past treatment for localized disease; the potential for this approach to reduce symptoms and improve QoL in men who have worse health may still be warranted.
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spelling pubmed-90165502022-04-20 Quality of Life of Prostate Cancer Survivors Participating in a Remotely Delivered Web-Based Behavioral Intervention Pilot Randomized Trial Langlais, Crystal S. Chen, Yea-Hung Van Blarigan, Erin L. Kenfield, Stacey A. Kessler, Elizabeth R. Daniel, Kimi Ramsdill, Justin W. Beer, Tomasz M. Graff, Rebecca E. Paich, Kellie Chan, June M. Winters-Stone, Kerri M. Integr Cancer Ther Research Article BACKGROUND: Following a prostate cancer (PC) diagnosis, treatment-related symptoms may result in diminished quality of life (QoL). Improved diet and increased exercise may improve QoL in men with PC. METHODS: We conducted a 4-arm pilot randomized trial to assess feasibility and acceptability of a 3-month web-based diet and exercise intervention, among men (>18 years of age) with PC (reported elsewhere). The purpose of this study is to describe the change in QoL measured by surveys (eg, QLQ-C30, PROMIS Fatigue) at enrollment and following the intervention. Men were randomized 1:1:1:1 to increasing levels of web-based behavioral support: Level 1: website; Level 2: Level 1 plus personalized diet and exercise prescription; Level 3: Levels 1-2 plus Fitbit and text messages; Level 4: Levels 1-3 plus 2 30-minute coaching calls. T-tests were used to compare pre-post change in mean QoL scores between each Level and Level 1. RESULTS: Two hundred and two men consented and were randomized (n = 49, 51, 50, 52 for Levels 1-4, respectively). Men were predominantly white (93%), with a median age of 70 years (Intra-quartile Range [IQR]: 65,75) and 3 years (IQR: 1,9) post primary treatment for mostly localized disease (74% with T1-2). There were no meaningful changes in QoL, but there were notable trends. Level 3 participants had small improvements in QLQ-C30 Global Health (5.46; 95% CI: −0.02, 10.95) compared to Level 1. In contrast, Level 2 participants trended toward decreasing Global QoL (−2.31, 95% CI: −8.05, 3.42), which may reflect declines in function (eg, Cognitive: −6.94, 95% CI: −13.76, −0.13) and higher symptom burden (eg, Diarrhea: 4.63, 95% CI: −1.48, 10.74). CONCLUSIONS: This short, web-based intervention did not appear to have an impact on PC survivors’ QoL. Most men were several years past treatment for localized disease; the potential for this approach to reduce symptoms and improve QoL in men who have worse health may still be warranted. SAGE Publications 2022-04-07 /pmc/articles/PMC9016550/ /pubmed/35389288 http://dx.doi.org/10.1177/15347354211063500 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Article
Langlais, Crystal S.
Chen, Yea-Hung
Van Blarigan, Erin L.
Kenfield, Stacey A.
Kessler, Elizabeth R.
Daniel, Kimi
Ramsdill, Justin W.
Beer, Tomasz M.
Graff, Rebecca E.
Paich, Kellie
Chan, June M.
Winters-Stone, Kerri M.
Quality of Life of Prostate Cancer Survivors Participating in a Remotely Delivered Web-Based Behavioral Intervention Pilot Randomized Trial
title Quality of Life of Prostate Cancer Survivors Participating in a Remotely Delivered Web-Based Behavioral Intervention Pilot Randomized Trial
title_full Quality of Life of Prostate Cancer Survivors Participating in a Remotely Delivered Web-Based Behavioral Intervention Pilot Randomized Trial
title_fullStr Quality of Life of Prostate Cancer Survivors Participating in a Remotely Delivered Web-Based Behavioral Intervention Pilot Randomized Trial
title_full_unstemmed Quality of Life of Prostate Cancer Survivors Participating in a Remotely Delivered Web-Based Behavioral Intervention Pilot Randomized Trial
title_short Quality of Life of Prostate Cancer Survivors Participating in a Remotely Delivered Web-Based Behavioral Intervention Pilot Randomized Trial
title_sort quality of life of prostate cancer survivors participating in a remotely delivered web-based behavioral intervention pilot randomized trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016550/
https://www.ncbi.nlm.nih.gov/pubmed/35389288
http://dx.doi.org/10.1177/15347354211063500
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