Directed Evolution-Driven Increase of Structural Plasticity Is a Prerequisite for Binding the Complement Lectin Pathway Blocking MASP-Inhibitor Peptides

[Image: see text] MASP-1 and MASP-2 are key activator proteases of the complement lectin pathway. The first specific mannose-binding lectin-associated serine protease (MASP) inhibitors had been developed from the 14-amino-acid sunflower trypsin inhibitor (SFTI) peptide by phage display, yielding SFT...

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Detalles Bibliográficos
Autores principales: Dürvanger, Zsolt, Boros, Eszter, Nagy, Zoltán Attila, Hegedüs, Rózsa, Megyeri, Márton, Dobó, József, Gál, Péter, Schlosser, Gitta, Ángyán, Annamária F., Gáspári, Zoltán, Perczel, András, Harmat, Veronika, Mező, Gábor, Menyhárd, Dóra K., Pál, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016712/
https://www.ncbi.nlm.nih.gov/pubmed/35378038
http://dx.doi.org/10.1021/acschembio.2c00114

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