Cargando…

Cognitive Dysfunction of Chikungunya Virus Infection in Older Adults

BACKGROUND: Chikungunya fever is a disabling articular disease caused by chikungunya virus (CHIKV). In the past decade it has affected millions of people across America, Africa, Asia, and Europe, turning this infection into a public health concern. The acute phase of chikungunya infection is usually...

Descripción completa

Detalles Bibliográficos
Autores principales: Peixoto, Vanessa Giffoni M. N. P., Azevedo, Julianna P., Luz, Kleber G., Almondes, Katie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016789/
https://www.ncbi.nlm.nih.gov/pubmed/35449568
http://dx.doi.org/10.3389/fpsyt.2022.823218
_version_ 1784688604055863296
author Peixoto, Vanessa Giffoni M. N. P.
Azevedo, Julianna P.
Luz, Kleber G.
Almondes, Katie M.
author_facet Peixoto, Vanessa Giffoni M. N. P.
Azevedo, Julianna P.
Luz, Kleber G.
Almondes, Katie M.
author_sort Peixoto, Vanessa Giffoni M. N. P.
collection PubMed
description BACKGROUND: Chikungunya fever is a disabling articular disease caused by chikungunya virus (CHIKV). In the past decade it has affected millions of people across America, Africa, Asia, and Europe, turning this infection into a public health concern. The acute phase of chikungunya infection is usually self-limiting, characterized by severe arthralgia, fever, chills, myalgia, headache, and rash. CHIKV neurovirulence is evident and seems to be higher among elders. Considering their susceptibility to cognitive decline and dementia, the aim of our study was to investigate whether CHIKV infection might cause long-term cognitive impairment in aged people. METHODS: A cross-sectional study was conducted with volunteers aged from 60 to 90 who had been affected by chikungunya and also with healthy controls. A structured questionnaire was used to record demographic and clinical data, functional status, and depression. Global cognitive function was assessed through MoCA. A comprehensive neuropsychological battery was performed to assess specific cognitive functions. RESULTS: Subjective memory complaints were present in 70% of subjects with previous chikungunya. This group had a poorer performance in MoCA (p = 0.000) and specific cognitive tests: Semantic (p = 0.05) and Phonemic Verbal Fluency (p = 0.003), 5-Digit (choice, reading, counting and alternance, p = 0.003, p = 0.014, p = 0.021, and p = 0.021, respectively), Stroop test (time, errors and interference, p = 0.000, p = 0.027 and p = 0.015, respectively), and RAVLT (word total session p = 0.05). These tests reflect performance on general executive functions, cognitive flexibility, inhibitory control, processing speed, semantic memory and episodic memory. CONCLUSION: Our data suggest that CHIKV infection may cause long-term cognitive decline in aged people and might be a risk factor for future dementia in this population.
format Online
Article
Text
id pubmed-9016789
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-90167892022-04-20 Cognitive Dysfunction of Chikungunya Virus Infection in Older Adults Peixoto, Vanessa Giffoni M. N. P. Azevedo, Julianna P. Luz, Kleber G. Almondes, Katie M. Front Psychiatry Psychiatry BACKGROUND: Chikungunya fever is a disabling articular disease caused by chikungunya virus (CHIKV). In the past decade it has affected millions of people across America, Africa, Asia, and Europe, turning this infection into a public health concern. The acute phase of chikungunya infection is usually self-limiting, characterized by severe arthralgia, fever, chills, myalgia, headache, and rash. CHIKV neurovirulence is evident and seems to be higher among elders. Considering their susceptibility to cognitive decline and dementia, the aim of our study was to investigate whether CHIKV infection might cause long-term cognitive impairment in aged people. METHODS: A cross-sectional study was conducted with volunteers aged from 60 to 90 who had been affected by chikungunya and also with healthy controls. A structured questionnaire was used to record demographic and clinical data, functional status, and depression. Global cognitive function was assessed through MoCA. A comprehensive neuropsychological battery was performed to assess specific cognitive functions. RESULTS: Subjective memory complaints were present in 70% of subjects with previous chikungunya. This group had a poorer performance in MoCA (p = 0.000) and specific cognitive tests: Semantic (p = 0.05) and Phonemic Verbal Fluency (p = 0.003), 5-Digit (choice, reading, counting and alternance, p = 0.003, p = 0.014, p = 0.021, and p = 0.021, respectively), Stroop test (time, errors and interference, p = 0.000, p = 0.027 and p = 0.015, respectively), and RAVLT (word total session p = 0.05). These tests reflect performance on general executive functions, cognitive flexibility, inhibitory control, processing speed, semantic memory and episodic memory. CONCLUSION: Our data suggest that CHIKV infection may cause long-term cognitive decline in aged people and might be a risk factor for future dementia in this population. Frontiers Media S.A. 2022-04-05 /pmc/articles/PMC9016789/ /pubmed/35449568 http://dx.doi.org/10.3389/fpsyt.2022.823218 Text en Copyright © 2022 Peixoto, Azevedo, Luz and Almondes. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Peixoto, Vanessa Giffoni M. N. P.
Azevedo, Julianna P.
Luz, Kleber G.
Almondes, Katie M.
Cognitive Dysfunction of Chikungunya Virus Infection in Older Adults
title Cognitive Dysfunction of Chikungunya Virus Infection in Older Adults
title_full Cognitive Dysfunction of Chikungunya Virus Infection in Older Adults
title_fullStr Cognitive Dysfunction of Chikungunya Virus Infection in Older Adults
title_full_unstemmed Cognitive Dysfunction of Chikungunya Virus Infection in Older Adults
title_short Cognitive Dysfunction of Chikungunya Virus Infection in Older Adults
title_sort cognitive dysfunction of chikungunya virus infection in older adults
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016789/
https://www.ncbi.nlm.nih.gov/pubmed/35449568
http://dx.doi.org/10.3389/fpsyt.2022.823218
work_keys_str_mv AT peixotovanessagiffonimnp cognitivedysfunctionofchikungunyavirusinfectioninolderadults
AT azevedojuliannap cognitivedysfunctionofchikungunyavirusinfectioninolderadults
AT luzkleberg cognitivedysfunctionofchikungunyavirusinfectioninolderadults
AT almondeskatiem cognitivedysfunctionofchikungunyavirusinfectioninolderadults