Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12)

[Image: see text] The catechol derivative RC-12 (WR 27653) (1) is one of the few non-8-aminoquinolines with good activity against hypnozoites in the gold-standard Plasmodium cynomolgi–rhesus monkey (Macaca mulatta) model, but in a small clinical trial, it had no efficacy against Plasmodium vivax hyp...

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Detalles Bibliográficos
Autores principales: Dong, Yuxiang, Sonawane, Yogesh, Maher, Steven P., Zeeman, Anne-Marie, Chaumeau, Victor, Vantaux, Amélie, Cooper, Caitlin A., Chiu, Francis C. K., Ryan, Eileen, McLaren, Jenna, Chen, Gong, Wittlin, Sergio, Witkowski, Benoît, Nosten, François, Sriraghavan, Kamaraj, Kyle, Dennis E., Kocken, Clemens H. M., Charman, Susan A., Vennerstrom, Jonathan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016807/
https://www.ncbi.nlm.nih.gov/pubmed/35449901
http://dx.doi.org/10.1021/acsomega.2c01099

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