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Overexpression of CDCA8 Predicts Poor Prognosis and Promotes Tumor Cell Growth in Prostate Cancer

Human cell division cycle-related protein 8 (CDCA8) is an essential component of the vertebrate chromosomal passenger complex (CPC). CDCA8 was confirmed to play a role in promoting malignant tumor progression. However, the exact function of CDCA8 in the development and progression of prostate cancer...

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Autores principales: Wan, Shun, He, Yang, Zhang, Bin, Yang, Zhi, Du, Fang-Ming, Zhang, Chun-Peng, Fu, Yu-Qiang, Mi, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016845/
https://www.ncbi.nlm.nih.gov/pubmed/35449575
http://dx.doi.org/10.3389/fonc.2022.784183
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author Wan, Shun
He, Yang
Zhang, Bin
Yang, Zhi
Du, Fang-Ming
Zhang, Chun-Peng
Fu, Yu-Qiang
Mi, Jun
author_facet Wan, Shun
He, Yang
Zhang, Bin
Yang, Zhi
Du, Fang-Ming
Zhang, Chun-Peng
Fu, Yu-Qiang
Mi, Jun
author_sort Wan, Shun
collection PubMed
description Human cell division cycle-related protein 8 (CDCA8) is an essential component of the vertebrate chromosomal passenger complex (CPC). CDCA8 was confirmed to play a role in promoting malignant tumor progression. However, the exact function of CDCA8 in the development and progression of prostate cancer (PCa) remains unclear. In this study, the database GSE69223 was downloaded by the gene expression omnibus (GEO) database, as well as CDCA8 expression differences in multiple tumor tissues and normal tissues were detected by The Cancer Genome Atlas (TCGA), TIMER, Oncomine, and Ualcan databases. Kaplan-Meier and Cox regression methods were used to analyze the correlation between CDCA8 expression and prognosis in PCa. We confirmed the expression of CDCA8 in PCa tissues by HPA. We also analyzed the association of CDCA8 expression with PCa clinical characteristics in the TCGA database. To further understand the role of CDCA8 in PCa, we assessed the effects of CDCA8 on PCa cell growth, proliferation, and migration in vitro studies. As a result, CDCA8 was significantly overexpressed in PCa cells compared with normal prostate cells. High CDCA8 expression predicts poor prognosis in PCa patients, and CDCA8 expression was higher in high-grade PCa. In addition, silencing of CDCA8 significantly inhibited PCa cell proliferation and migration. In summary, CDCA8 promoted the proliferation and migration of PCa cells.
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spelling pubmed-90168452022-04-20 Overexpression of CDCA8 Predicts Poor Prognosis and Promotes Tumor Cell Growth in Prostate Cancer Wan, Shun He, Yang Zhang, Bin Yang, Zhi Du, Fang-Ming Zhang, Chun-Peng Fu, Yu-Qiang Mi, Jun Front Oncol Oncology Human cell division cycle-related protein 8 (CDCA8) is an essential component of the vertebrate chromosomal passenger complex (CPC). CDCA8 was confirmed to play a role in promoting malignant tumor progression. However, the exact function of CDCA8 in the development and progression of prostate cancer (PCa) remains unclear. In this study, the database GSE69223 was downloaded by the gene expression omnibus (GEO) database, as well as CDCA8 expression differences in multiple tumor tissues and normal tissues were detected by The Cancer Genome Atlas (TCGA), TIMER, Oncomine, and Ualcan databases. Kaplan-Meier and Cox regression methods were used to analyze the correlation between CDCA8 expression and prognosis in PCa. We confirmed the expression of CDCA8 in PCa tissues by HPA. We also analyzed the association of CDCA8 expression with PCa clinical characteristics in the TCGA database. To further understand the role of CDCA8 in PCa, we assessed the effects of CDCA8 on PCa cell growth, proliferation, and migration in vitro studies. As a result, CDCA8 was significantly overexpressed in PCa cells compared with normal prostate cells. High CDCA8 expression predicts poor prognosis in PCa patients, and CDCA8 expression was higher in high-grade PCa. In addition, silencing of CDCA8 significantly inhibited PCa cell proliferation and migration. In summary, CDCA8 promoted the proliferation and migration of PCa cells. Frontiers Media S.A. 2022-04-05 /pmc/articles/PMC9016845/ /pubmed/35449575 http://dx.doi.org/10.3389/fonc.2022.784183 Text en Copyright © 2022 Wan, He, Zhang, Yang, Du, Zhang, Fu and Mi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wan, Shun
He, Yang
Zhang, Bin
Yang, Zhi
Du, Fang-Ming
Zhang, Chun-Peng
Fu, Yu-Qiang
Mi, Jun
Overexpression of CDCA8 Predicts Poor Prognosis and Promotes Tumor Cell Growth in Prostate Cancer
title Overexpression of CDCA8 Predicts Poor Prognosis and Promotes Tumor Cell Growth in Prostate Cancer
title_full Overexpression of CDCA8 Predicts Poor Prognosis and Promotes Tumor Cell Growth in Prostate Cancer
title_fullStr Overexpression of CDCA8 Predicts Poor Prognosis and Promotes Tumor Cell Growth in Prostate Cancer
title_full_unstemmed Overexpression of CDCA8 Predicts Poor Prognosis and Promotes Tumor Cell Growth in Prostate Cancer
title_short Overexpression of CDCA8 Predicts Poor Prognosis and Promotes Tumor Cell Growth in Prostate Cancer
title_sort overexpression of cdca8 predicts poor prognosis and promotes tumor cell growth in prostate cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016845/
https://www.ncbi.nlm.nih.gov/pubmed/35449575
http://dx.doi.org/10.3389/fonc.2022.784183
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