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Hafnium-Based Metal–Organic Framework Nanoparticles as a Radiosensitizer to Improve Radiotherapy Efficacy in Esophageal Cancer

[Image: see text] Radiotherapy is one of the most widely used clinical treatments for tumors, but it faces limitations, such as poor X-ray retention at the tumor site. The use of radiosensitizers containing high Z elements is an effective way to enhance X-ray absorption. Here, we demonstrate a simpl...

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Autores principales: Zhou, Wei, Liu, Zhulong, Wang, Nana, Chen, Xue, Sun, Xiaozheng, Cheng, Yufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016869/
https://www.ncbi.nlm.nih.gov/pubmed/35449918
http://dx.doi.org/10.1021/acsomega.2c00223
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author Zhou, Wei
Liu, Zhulong
Wang, Nana
Chen, Xue
Sun, Xiaozheng
Cheng, Yufeng
author_facet Zhou, Wei
Liu, Zhulong
Wang, Nana
Chen, Xue
Sun, Xiaozheng
Cheng, Yufeng
author_sort Zhou, Wei
collection PubMed
description [Image: see text] Radiotherapy is one of the most widely used clinical treatments for tumors, but it faces limitations, such as poor X-ray retention at the tumor site. The use of radiosensitizers containing high Z elements is an effective way to enhance X-ray absorption. Here, we demonstrate a simple one-step method for the synthesis of UiO-66-NH(2)(Hf) metal–organic framework nanoparticles for use as radiosensitizers in radiotherapy. The UiO-66-NH(2)(Hf) nanoparticles had a diameter of less than 100 nm and were stable in the physiological environment. UiO-66-NH(2)(Hf) induced apoptosis by enhancing X-ray absorption, as confirmed by in vitro and in vivo experiments. These characteristics make UiO-66-NH(2)(Hf) a promising radiosensitizer for esophageal cancer radiotherapy.
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spelling pubmed-90168692022-04-20 Hafnium-Based Metal–Organic Framework Nanoparticles as a Radiosensitizer to Improve Radiotherapy Efficacy in Esophageal Cancer Zhou, Wei Liu, Zhulong Wang, Nana Chen, Xue Sun, Xiaozheng Cheng, Yufeng ACS Omega [Image: see text] Radiotherapy is one of the most widely used clinical treatments for tumors, but it faces limitations, such as poor X-ray retention at the tumor site. The use of radiosensitizers containing high Z elements is an effective way to enhance X-ray absorption. Here, we demonstrate a simple one-step method for the synthesis of UiO-66-NH(2)(Hf) metal–organic framework nanoparticles for use as radiosensitizers in radiotherapy. The UiO-66-NH(2)(Hf) nanoparticles had a diameter of less than 100 nm and were stable in the physiological environment. UiO-66-NH(2)(Hf) induced apoptosis by enhancing X-ray absorption, as confirmed by in vitro and in vivo experiments. These characteristics make UiO-66-NH(2)(Hf) a promising radiosensitizer for esophageal cancer radiotherapy. American Chemical Society 2022-03-30 /pmc/articles/PMC9016869/ /pubmed/35449918 http://dx.doi.org/10.1021/acsomega.2c00223 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Zhou, Wei
Liu, Zhulong
Wang, Nana
Chen, Xue
Sun, Xiaozheng
Cheng, Yufeng
Hafnium-Based Metal–Organic Framework Nanoparticles as a Radiosensitizer to Improve Radiotherapy Efficacy in Esophageal Cancer
title Hafnium-Based Metal–Organic Framework Nanoparticles as a Radiosensitizer to Improve Radiotherapy Efficacy in Esophageal Cancer
title_full Hafnium-Based Metal–Organic Framework Nanoparticles as a Radiosensitizer to Improve Radiotherapy Efficacy in Esophageal Cancer
title_fullStr Hafnium-Based Metal–Organic Framework Nanoparticles as a Radiosensitizer to Improve Radiotherapy Efficacy in Esophageal Cancer
title_full_unstemmed Hafnium-Based Metal–Organic Framework Nanoparticles as a Radiosensitizer to Improve Radiotherapy Efficacy in Esophageal Cancer
title_short Hafnium-Based Metal–Organic Framework Nanoparticles as a Radiosensitizer to Improve Radiotherapy Efficacy in Esophageal Cancer
title_sort hafnium-based metal–organic framework nanoparticles as a radiosensitizer to improve radiotherapy efficacy in esophageal cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016869/
https://www.ncbi.nlm.nih.gov/pubmed/35449918
http://dx.doi.org/10.1021/acsomega.2c00223
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