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Hafnium-Based Metal–Organic Framework Nanoparticles as a Radiosensitizer to Improve Radiotherapy Efficacy in Esophageal Cancer
[Image: see text] Radiotherapy is one of the most widely used clinical treatments for tumors, but it faces limitations, such as poor X-ray retention at the tumor site. The use of radiosensitizers containing high Z elements is an effective way to enhance X-ray absorption. Here, we demonstrate a simpl...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016869/ https://www.ncbi.nlm.nih.gov/pubmed/35449918 http://dx.doi.org/10.1021/acsomega.2c00223 |
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author | Zhou, Wei Liu, Zhulong Wang, Nana Chen, Xue Sun, Xiaozheng Cheng, Yufeng |
author_facet | Zhou, Wei Liu, Zhulong Wang, Nana Chen, Xue Sun, Xiaozheng Cheng, Yufeng |
author_sort | Zhou, Wei |
collection | PubMed |
description | [Image: see text] Radiotherapy is one of the most widely used clinical treatments for tumors, but it faces limitations, such as poor X-ray retention at the tumor site. The use of radiosensitizers containing high Z elements is an effective way to enhance X-ray absorption. Here, we demonstrate a simple one-step method for the synthesis of UiO-66-NH(2)(Hf) metal–organic framework nanoparticles for use as radiosensitizers in radiotherapy. The UiO-66-NH(2)(Hf) nanoparticles had a diameter of less than 100 nm and were stable in the physiological environment. UiO-66-NH(2)(Hf) induced apoptosis by enhancing X-ray absorption, as confirmed by in vitro and in vivo experiments. These characteristics make UiO-66-NH(2)(Hf) a promising radiosensitizer for esophageal cancer radiotherapy. |
format | Online Article Text |
id | pubmed-9016869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-90168692022-04-20 Hafnium-Based Metal–Organic Framework Nanoparticles as a Radiosensitizer to Improve Radiotherapy Efficacy in Esophageal Cancer Zhou, Wei Liu, Zhulong Wang, Nana Chen, Xue Sun, Xiaozheng Cheng, Yufeng ACS Omega [Image: see text] Radiotherapy is one of the most widely used clinical treatments for tumors, but it faces limitations, such as poor X-ray retention at the tumor site. The use of radiosensitizers containing high Z elements is an effective way to enhance X-ray absorption. Here, we demonstrate a simple one-step method for the synthesis of UiO-66-NH(2)(Hf) metal–organic framework nanoparticles for use as radiosensitizers in radiotherapy. The UiO-66-NH(2)(Hf) nanoparticles had a diameter of less than 100 nm and were stable in the physiological environment. UiO-66-NH(2)(Hf) induced apoptosis by enhancing X-ray absorption, as confirmed by in vitro and in vivo experiments. These characteristics make UiO-66-NH(2)(Hf) a promising radiosensitizer for esophageal cancer radiotherapy. American Chemical Society 2022-03-30 /pmc/articles/PMC9016869/ /pubmed/35449918 http://dx.doi.org/10.1021/acsomega.2c00223 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Zhou, Wei Liu, Zhulong Wang, Nana Chen, Xue Sun, Xiaozheng Cheng, Yufeng Hafnium-Based Metal–Organic Framework Nanoparticles as a Radiosensitizer to Improve Radiotherapy Efficacy in Esophageal Cancer |
title | Hafnium-Based Metal–Organic Framework Nanoparticles
as a Radiosensitizer to Improve Radiotherapy Efficacy in Esophageal
Cancer |
title_full | Hafnium-Based Metal–Organic Framework Nanoparticles
as a Radiosensitizer to Improve Radiotherapy Efficacy in Esophageal
Cancer |
title_fullStr | Hafnium-Based Metal–Organic Framework Nanoparticles
as a Radiosensitizer to Improve Radiotherapy Efficacy in Esophageal
Cancer |
title_full_unstemmed | Hafnium-Based Metal–Organic Framework Nanoparticles
as a Radiosensitizer to Improve Radiotherapy Efficacy in Esophageal
Cancer |
title_short | Hafnium-Based Metal–Organic Framework Nanoparticles
as a Radiosensitizer to Improve Radiotherapy Efficacy in Esophageal
Cancer |
title_sort | hafnium-based metal–organic framework nanoparticles
as a radiosensitizer to improve radiotherapy efficacy in esophageal
cancer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016869/ https://www.ncbi.nlm.nih.gov/pubmed/35449918 http://dx.doi.org/10.1021/acsomega.2c00223 |
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