Cargando…
Plasma and aqueous levels of alarin and adipsin ın patients with and without diabetic retinopathy
BACKROUND: Diabetic retinopathy is a disease seen with microvascular complications as a result of hyperglycemia and insulin resistance. Alarin and Adipsin are molecules with a role in energy and glucose metabolism. The aim of this study was to determine plasma and aqueous levels of Alarin and Adipsi...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016965/ https://www.ncbi.nlm.nih.gov/pubmed/35436912 http://dx.doi.org/10.1186/s12886-022-02403-0 |
_version_ | 1784688670668750848 |
---|---|
author | Gül, Fatih Cem Kobat, Sabiha Güngör Çelik, Fatih Aydin, Süleyman Akkoç, Ramazan Fazıl |
author_facet | Gül, Fatih Cem Kobat, Sabiha Güngör Çelik, Fatih Aydin, Süleyman Akkoç, Ramazan Fazıl |
author_sort | Gül, Fatih Cem |
collection | PubMed |
description | BACKROUND: Diabetic retinopathy is a disease seen with microvascular complications as a result of hyperglycemia and insulin resistance. Alarin and Adipsin are molecules with a role in energy and glucose metabolism. The aim of this study was to determine plasma and aqueous levels of Alarin and Adipsin in patients with and without diabetic retinopathy to evaluate their potential roles in diabetic retinopathy. METHODS: The study included one eye from each of 20 cataract patients without diabetes (C), 20 cataract patients with diabetes and without diabetic retinopathy (DM + C), and 20 cataract patients with diabetes and diabetic retinopathy (DR + C). Plasma and aqueous humour samples were taken from all patients during the cataract operation. Alarin and Adipsin levels were examined with the enzyme-linked immunosorbent assay (ELISA) method. RESULTS: Both plasma and aqueous Alarin levels were significantly higher in the patients with diabetic retinopathy than in the control group (p < 0.001, p = 0.006). Adipsin levels were found to be significantly higher in plasma in the control group than in the DR + C group and significantly higher in aqueous in the DR + C group than in the control group (p < 0.001, p < 0.001). CONCLUSION: These findings suggest that Alarin and Adipsin may play important role in diabetic retinopathy. |
format | Online Article Text |
id | pubmed-9016965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-90169652022-04-20 Plasma and aqueous levels of alarin and adipsin ın patients with and without diabetic retinopathy Gül, Fatih Cem Kobat, Sabiha Güngör Çelik, Fatih Aydin, Süleyman Akkoç, Ramazan Fazıl BMC Ophthalmol Research BACKROUND: Diabetic retinopathy is a disease seen with microvascular complications as a result of hyperglycemia and insulin resistance. Alarin and Adipsin are molecules with a role in energy and glucose metabolism. The aim of this study was to determine plasma and aqueous levels of Alarin and Adipsin in patients with and without diabetic retinopathy to evaluate their potential roles in diabetic retinopathy. METHODS: The study included one eye from each of 20 cataract patients without diabetes (C), 20 cataract patients with diabetes and without diabetic retinopathy (DM + C), and 20 cataract patients with diabetes and diabetic retinopathy (DR + C). Plasma and aqueous humour samples were taken from all patients during the cataract operation. Alarin and Adipsin levels were examined with the enzyme-linked immunosorbent assay (ELISA) method. RESULTS: Both plasma and aqueous Alarin levels were significantly higher in the patients with diabetic retinopathy than in the control group (p < 0.001, p = 0.006). Adipsin levels were found to be significantly higher in plasma in the control group than in the DR + C group and significantly higher in aqueous in the DR + C group than in the control group (p < 0.001, p < 0.001). CONCLUSION: These findings suggest that Alarin and Adipsin may play important role in diabetic retinopathy. BioMed Central 2022-04-18 /pmc/articles/PMC9016965/ /pubmed/35436912 http://dx.doi.org/10.1186/s12886-022-02403-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Gül, Fatih Cem Kobat, Sabiha Güngör Çelik, Fatih Aydin, Süleyman Akkoç, Ramazan Fazıl Plasma and aqueous levels of alarin and adipsin ın patients with and without diabetic retinopathy |
title | Plasma and aqueous levels of alarin and adipsin ın patients with and without diabetic retinopathy |
title_full | Plasma and aqueous levels of alarin and adipsin ın patients with and without diabetic retinopathy |
title_fullStr | Plasma and aqueous levels of alarin and adipsin ın patients with and without diabetic retinopathy |
title_full_unstemmed | Plasma and aqueous levels of alarin and adipsin ın patients with and without diabetic retinopathy |
title_short | Plasma and aqueous levels of alarin and adipsin ın patients with and without diabetic retinopathy |
title_sort | plasma and aqueous levels of alarin and adipsin ın patients with and without diabetic retinopathy |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016965/ https://www.ncbi.nlm.nih.gov/pubmed/35436912 http://dx.doi.org/10.1186/s12886-022-02403-0 |
work_keys_str_mv | AT gulfatihcem plasmaandaqueouslevelsofalarinandadipsinınpatientswithandwithoutdiabeticretinopathy AT kobatsabihagungor plasmaandaqueouslevelsofalarinandadipsinınpatientswithandwithoutdiabeticretinopathy AT celikfatih plasmaandaqueouslevelsofalarinandadipsinınpatientswithandwithoutdiabeticretinopathy AT aydinsuleyman plasmaandaqueouslevelsofalarinandadipsinınpatientswithandwithoutdiabeticretinopathy AT akkocramazanfazıl plasmaandaqueouslevelsofalarinandadipsinınpatientswithandwithoutdiabeticretinopathy |