Modular Framework for Simulation-Based Multi-objective Optimization of a Cryogenic Air Separation Unit

[Image: see text] A framework to obtain optimal operating conditions is proposed for a cryogenic air separation unit case study. The optimization problem is formulated considering three objective functions, 11 decision variables, and two constraint setups. Different optimization algorithms simultaneously evaluate the conflicting objective functions: the annualized cash flow, the efficiency at the compression stage, and capital expenditures. The framework follows a modular approach, in which the process simulator PRO/II and a Python environment are combined. The results permit us to assess the applicability of the tested algorithms and to determine optimal operational windows based on the resultant 3-D Pareto fronts.