A taste of the early steps in BAX activation with FLAMBE

The activation of BAX through intricate intramolecular changes is critical for apoptosis. In this issue of Cell Reports Methods, Gelles et al. report engineering FLAMBE, an elegant fluorescence polarization ligand assay for monitoring the early activation of monomeric BAX via real-time release of a...

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Detalles Bibliográficos
Autores principales: Gil, Melanie, Hanna, Marina R., Gama, Vivian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017131/
https://www.ncbi.nlm.nih.gov/pubmed/35475223
http://dx.doi.org/10.1016/j.crmeth.2022.100190
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author Gil, Melanie
Hanna, Marina R.
Gama, Vivian
author_facet Gil, Melanie
Hanna, Marina R.
Gama, Vivian
author_sort Gil, Melanie
collection PubMed
description The activation of BAX through intricate intramolecular changes is critical for apoptosis. In this issue of Cell Reports Methods, Gelles et al. report engineering FLAMBE, an elegant fluorescence polarization ligand assay for monitoring the early activation of monomeric BAX via real-time release of a peptide probe, expanding the repertoire of BAX activation assays to the single-molecule level.
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spelling pubmed-90171312022-04-25 A taste of the early steps in BAX activation with FLAMBE Gil, Melanie Hanna, Marina R. Gama, Vivian Cell Rep Methods Preview The activation of BAX through intricate intramolecular changes is critical for apoptosis. In this issue of Cell Reports Methods, Gelles et al. report engineering FLAMBE, an elegant fluorescence polarization ligand assay for monitoring the early activation of monomeric BAX via real-time release of a peptide probe, expanding the repertoire of BAX activation assays to the single-molecule level. Elsevier 2022-03-15 /pmc/articles/PMC9017131/ /pubmed/35475223 http://dx.doi.org/10.1016/j.crmeth.2022.100190 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preview
Gil, Melanie
Hanna, Marina R.
Gama, Vivian
A taste of the early steps in BAX activation with FLAMBE
title A taste of the early steps in BAX activation with FLAMBE
title_full A taste of the early steps in BAX activation with FLAMBE
title_fullStr A taste of the early steps in BAX activation with FLAMBE
title_full_unstemmed A taste of the early steps in BAX activation with FLAMBE
title_short A taste of the early steps in BAX activation with FLAMBE
title_sort taste of the early steps in bax activation with flambe
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017131/
https://www.ncbi.nlm.nih.gov/pubmed/35475223
http://dx.doi.org/10.1016/j.crmeth.2022.100190
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