A multidimensional HIV-1 persistence model for clonal expansion and viral rebound in vitro

Using a replication-competent virus for prolonged in vitro culture, Matsuda et al. captured the heterogenous HIV-1 genome and integration site landscape, examined viral cytopathic effects and clonal expansion capacity, and tested drugs that can eliminate HIV-1-infected cells.

Detalles Bibliográficos
Autores principales: Eshetu, Amare, Ho, Ya-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017154/
https://www.ncbi.nlm.nih.gov/pubmed/35475216
http://dx.doi.org/10.1016/j.crmeth.2021.100134
Descripción
Sumario:Using a replication-competent virus for prolonged in vitro culture, Matsuda et al. captured the heterogenous HIV-1 genome and integration site landscape, examined viral cytopathic effects and clonal expansion capacity, and tested drugs that can eliminate HIV-1-infected cells.

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