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Extracting functional insights from loss-of-function screens using deep link prediction

We present deep link prediction (DLP), a method for the interpretation of loss-of-function screens. Our approach uses representation-based link prediction to reprioritize phenotypic readouts by integrating screening experiments with gene-gene interaction networks. We validate on 2 different loss-of-...

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Detalles Bibliográficos
Autores principales:	Strybol, Pieter-Paul, Larmuseau, Maarten, de Schaetzen van Brienen, Louise, Van den Bulcke, Tim, Marchal, Kathleen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017186/ https://www.ncbi.nlm.nih.gov/pubmed/35474966 http://dx.doi.org/10.1016/j.crmeth.2022.100171

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