Autologous humanized mouse models of iPSC-derived tumors enable characterization and modulation of cancer-immune cell interactions

Modeling the tumor-immune cell interactions in humanized mice is complex and limits drug development. Here, we generated easily accessible tumor models by transforming either primary skin fibroblasts or induced pluripotent stem cell-derived cell lines injected in immune-deficient mice reconstituted...

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Detalles Bibliográficos
Autores principales: Moquin-Beaudry, Gaël, Benabdallah, Basma, Maggiorani, Damien, Le, Oanh, Li, Yuanyi, Colas, Chloé, Raggi, Claudia, Ellezam, Benjamin, M'Callum, Marie-Agnès, Dal Soglio, Dorothée, Guimond, Jean V., Paganelli, Massimiliano, Haddad, Elie, Beauséjour, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017190/
https://www.ncbi.nlm.nih.gov/pubmed/35474871
http://dx.doi.org/10.1016/j.crmeth.2021.100153

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