NMR Molecular Replacement Provides New Insights into Binding Modes to Bromodomains of BRD4 and TRIM24

[Image: see text] Structure-based drug discovery (SBDD) largely relies on structural information from X-ray crystallography because traditional NMR structure calculation methods are too time consuming to be aligned with typical drug discovery timelines. The recently developed NMR molecular replaceme...

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Detalles Bibliográficos
Autores principales: Torres, Felix, Walser, Reto, Kaderli, Janina, Rossi, Emanuele, Bobby, Romel, Packer, Martin J., Sarda, Sunil, Walker, Graeme, Hitchin, James R., Milbradt, Alexander G., Orts, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017284/
https://www.ncbi.nlm.nih.gov/pubmed/35357834
http://dx.doi.org/10.1021/acs.jmedchem.1c01703

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