Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones

Described here is a series of spiropyrimidinetrione (SPT) compounds with activity against Mycobacterium tuberculosis through inhibition of DNA gyrase. The SPT class operates via a novel mode of inhibition, which involves Mg(2+)-independent stabilization of the DNA cleavage complex with DNA gyrase an...

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Detalles Bibliográficos
Autores principales: Basarab, Gregory S., Ghorpade, Sandeep, Gibhard, Liezl, Mueller, Rudolf, Njoroge, Mathew, Peton, Nashied, Govender, Preshendren, Massoudi, Lisa M., Robertson, Gregory Thomas, Lenaerts, Anne J., Boshoff, Helena Ingrid, Joerss, Douglas, Parish, Tanya, Durand-Reville, Thomas F., Perros, Manos, Singh, Vinayak, Chibale, Kelly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017349/
https://www.ncbi.nlm.nih.gov/pubmed/35266826
http://dx.doi.org/10.1128/aac.02192-21

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