Combination of Mycobacterium tuberculosis RS Ratio and CFU Improves the Ability of Murine Efficacy Experiments to Distinguish between Drug Treatments

Murine tuberculosis drug efficacy studies have historically monitored bacterial burden based on CFU of Mycobacterium tuberculosis in lung homogenate. In an alternative approach, a recently described molecular pharmacodynamic marker called the RS ratio quantifies drug effect on a fundamental cellular...

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Detalles Bibliográficos
Autores principales: Dide-Agossou, Christian, Bauman, Allison A., Ramey, Michelle E., Rossmassler, Karen, Al Mubarak, Reem, Pauly, Samantha, Voskuil, Martin I., Garcia-Cremades, Maria, Savic, Rada M., Nahid, Payam, Moore, Camille M., Tasneen, Rokeya, Nuermberger, Eric L., Robertson, Gregory T., Walter, Nicholas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017352/
https://www.ncbi.nlm.nih.gov/pubmed/35311519
http://dx.doi.org/10.1128/aac.02310-21

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