Cargando…

SLC38A10 Regulate Glutamate Homeostasis and Modulate the AKT/TSC2/mTOR Pathway in Mouse Primary Cortex Cells

Glutamate acts as a critical regulator of neurotransmitter balance, recycling, synaptic function and homeostasis in the brain and glutamate transporters control glutamate levels in the brain. SLC38A10 is a member of the SLC38 family and regulates protein synthesis and cellular stress responses. Here...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tripathi, Rekha, Aggarwal, Tanya, Lindberg, Frida A., Klemm, Anna H., Fredriksson, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017388/ https://www.ncbi.nlm.nih.gov/pubmed/35450293 http://dx.doi.org/10.3389/fcell.2022.854397

Ejemplares similares

SLC38A10 Transporter Plays a Role in Cell Survival Under Oxidative Stress and Glutamate Toxicity
por: Tripathi, Rekha, et al.
Publicado: (2021)

SLC38A10 Deficiency in Mice Affects Plasma Levels of Threonine and Histidine in Males but Not in Females: A Preliminary Characterization Study of SLC38A10(−/−) Mice
por: Lindberg, Frida A., et al.
Publicado: (2023)

Nutritional Stress Induced by Amino Acid Starvation Results in Changes for Slc38 Transporters in Immortalized Hypothalamic Neuronal Cells and Primary Cortex Cells
por: Hellsten, Sofie V., et al.
Publicado: (2018)

Behavioral profiling of SLC38A10 knockout mice using the multivariate concentric square field(TM) test
por: Lindberg, Frida A., et al.
Publicado: (2022)

SLC38A10 Knockout Mice Display a Decreased Body Weight and an Increased Risk-Taking Behavior in the Open Field Test
por: Lindberg, Frida A., et al.
Publicado: (2022)

The TSC-mTOR pathway regulates macrophage polarization
por: Byles, Vanessa, et al.
Publicado: (2013)

Potential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathway
por: Presneau, N, et al.
Publicado: (2009)

Knockdown of SLC38 Transporter Ortholog – CG13743 Reveals a Metabolic Relevance in Drosophila
por: Aggarwal, Tanya, et al.
Publicado: (2020)

The Human Cytomegalovirus U(L)38 protein drives mTOR-independent metabolic flux reprogramming by inhibiting TSC2
por: Rodríguez-Sánchez, Irene, et al.
Publicado: (2019)

SLC38A10 (SNAT10) is Located in ER and Golgi Compartments and Has a Role in Regulating Nascent Protein Synthesis
por: Tripathi, Rekha, et al.
Publicado: (2019)

Evaluation of Hsp90 and mTOR inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer
por: Mrozek, Evelyn M., et al.
Publicado: (2021)

TSC1/mTOR-controlled metabolic–epigenetic cross talk underpins DC control of CD8(+) T-cell homeostasis
por: Shi, Lei, et al.
Publicado: (2019)

Is mTOR Inhibitor Good Enough for Treatment All Tumors in TSC Patients?
por: Habib, Samy L, et al.
Publicado: (2016)

PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer
por: Zhang, Yanjie, et al.
Publicado: (2015)

The neuronal and astrocytic protein SLC38A10 transports glutamine, glutamate, and aspartate, suggesting a role in neurotransmission
por: Hellsten, Sofie V., et al.
Publicado: (2017)

Insight into response to mTOR inhibition when PKD1 and TSC2 are mutated
por: Cabrera-López, Cristina, et al.
Publicado: (2015)

Methylation of Hypothalamic Tsc1-mTOR Signaling in Regulation of Obesity and Obesity Resistance
por: Wang, Yanli, et al.
Publicado: (2020)

MicroRNA Expression Profile in TSC Cell Lines and the Impact of mTOR Inhibitor
por: Pawlik, Bartłomiej, et al.
Publicado: (2022)

Seizure reduction in TSC2‐mutant mouse model by an mTOR catalytic inhibitor
por: Dhamne, Sameer C., et al.
Publicado: (2023)

Hyperbaric oxygen relieves neuropathic pain through AKT/TSC2/mTOR pathway activity to induce autophagy
por: Liu, Yong-Da, et al.
Publicado: (2019)

Carboxy Terminal Tail of Polycystin-1 Regulates Localization of TSC2 to Repress mTOR
por: Dere, Ruhee, et al.
Publicado: (2010)

Effects of antiepileptic drugs in a new TSC/mTOR‐dependent epilepsy mouse model
por: Koene, Linda M. C., et al.
Publicado: (2019)

The mTOR pathway genes mTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function
por: Nguyen, Lena H., et al.
Publicado: (2023)

Treatment effect of mTOR-inhibition on tissue composition of renal angiomyolipomas in tuberous sclerosis complex (TSC)
por: Brakemeier, Susanne, et al.
Publicado: (2017)

TSC1 and DEPDC5 regulate HIV-1 latency through the mTOR signaling pathway
por: Jin, Shan, et al.
Publicado: (2018)

Leucine-Rich Glioma Inactivated 1 Promotes Oligodendrocyte Differentiation and Myelination via TSC-mTOR Signaling
por: Xie, Ya-Jun, et al.
Publicado: (2018)

Three-Year Follow-Up after Intrauterine mTOR Inhibitor Administration for Fetus with TSC-Associated Rhabdomyoma
por: Maász, Anita, et al.
Publicado: (2023)

Long non-coding RNA MEG3 promotes cisplatin-induced nephrotoxicity through regulating AKT/TSC/mTOR-mediated autophagy
por: Jing, Xu, et al.
Publicado: (2021)

Glutamate transporter-dependent mTOR phosphorylation in Müller glia cells
por: María López-Colomé, Ana, et al.
Publicado: (2012)

Homeostasis and the Importance for a Balance Between AKT/mTOR Activity and Intracellular Signaling
por: Altomare, DA, et al.
Publicado: (2012)

Excitotoxic glutamate causes neuronal insulin resistance by inhibiting insulin receptor/Akt/mTOR pathway
por: Pomytkin, Igor, et al.
Publicado: (2019)

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
por: Chen, Chong, et al.
Publicado: (2008)

Involvement of TSC genes and differential expression of other members of the mTOR signaling pathway in oral squamous cell carcinoma
por: Chakraborty, Sanjukta, et al.
Publicado: (2008)

Role of FIP200 in cardiac and liver development and its regulation of TNFα and TSC–mTOR signaling pathways
por: Gan, Boyi, et al.
Publicado: (2006)

Amplification of the Angiogenic Signal through the Activation of the TSC/mTOR/HIF Axis by the KSHV vGPCR in Kaposi's Sarcoma
por: Jham, Bruno C., et al.
Publicado: (2011)

Erzhi Pill® Repairs Experimental Liver Injury via TSC/mTOR Signaling Pathway Inhibiting Excessive Apoptosis
por: Zhou, Bu-gao, et al.
Publicado: (2017)

Electroacupuncture Upregulated Ghrelin in Rats with Functional Dyspepsia via AMPK/TSC2/Rheb-Mediated mTOR Inhibition
por: Tang, Lei, et al.
Publicado: (2019)

mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticus
por: Petrasek, Tomas, et al.
Publicado: (2021)

GPNMB expression identifies TSC1/2/mTOR‐associated and MiT family translocation‐driven renal neoplasms
por: Salles, Daniela C, et al.
Publicado: (2022)

Zinc-finger protein CXXC5 promotes breast carcinogenesis by regulating the TSC1/mTOR signaling pathway
por: Wang, Wenjuan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cbim373tisitclufe2a1aa5rqt