Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population

Coronary artery disease (CAD) is one of the leading causes of death in Europe. It is known that atherosclerosis is the primary risk factor of CAD development. MMP-9 is involved in all stages of atherosclerosis and thus may contribute to CAD emergence. To investigate the influence of MMP-9 on the (CA...

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Autores principales: Pogorielova, Oksana S., Korniienko, Viktoriia V., Chumachenko, Yaroslav D., Obukhova, Olha A., Martsovenko, Igor, Harbuzova, Viktoriia Yu.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017573/
https://www.ncbi.nlm.nih.gov/pubmed/35449607
http://dx.doi.org/10.1155/2022/2067632
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author Pogorielova, Oksana S.
Korniienko, Viktoriia V.
Chumachenko, Yaroslav D.
Obukhova, Olha A.
Martsovenko, Igor
Harbuzova, Viktoriia Yu.
author_facet Pogorielova, Oksana S.
Korniienko, Viktoriia V.
Chumachenko, Yaroslav D.
Obukhova, Olha A.
Martsovenko, Igor
Harbuzova, Viktoriia Yu.
author_sort Pogorielova, Oksana S.
collection PubMed
description Coronary artery disease (CAD) is one of the leading causes of death in Europe. It is known that atherosclerosis is the primary risk factor of CAD development. MMP-9 is involved in all stages of atherosclerosis and thus may contribute to CAD emergence. To investigate the influence of MMP-9 on the (CAD) development 25 patients with intact coronary arteries (CA), 40 patients with acute coronary syndrome (ACS), and 63 patients with chronic coronary syndrome (CCS) were enrolled in the study. Real-time PCR was carried out for genotyping on the rs17567-polymorphic locus, and ELISA study was performed to measure the MMP-9 plasma concentration. It was found the lower risk of MI occurrence for AG-carriers (P(a)=0.023; OR(a) = 0.299, 95% CI = 0.106–0.848) in Ukrainian population.
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spelling pubmed-90175732022-04-20 Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population Pogorielova, Oksana S. Korniienko, Viktoriia V. Chumachenko, Yaroslav D. Obukhova, Olha A. Martsovenko, Igor Harbuzova, Viktoriia Yu. Cardiol Res Pract Research Article Coronary artery disease (CAD) is one of the leading causes of death in Europe. It is known that atherosclerosis is the primary risk factor of CAD development. MMP-9 is involved in all stages of atherosclerosis and thus may contribute to CAD emergence. To investigate the influence of MMP-9 on the (CAD) development 25 patients with intact coronary arteries (CA), 40 patients with acute coronary syndrome (ACS), and 63 patients with chronic coronary syndrome (CCS) were enrolled in the study. Real-time PCR was carried out for genotyping on the rs17567-polymorphic locus, and ELISA study was performed to measure the MMP-9 plasma concentration. It was found the lower risk of MI occurrence for AG-carriers (P(a)=0.023; OR(a) = 0.299, 95% CI = 0.106–0.848) in Ukrainian population. Hindawi 2022-04-11 /pmc/articles/PMC9017573/ /pubmed/35449607 http://dx.doi.org/10.1155/2022/2067632 Text en Copyright © 2022 Oksana S. Pogorielova et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Pogorielova, Oksana S.
Korniienko, Viktoriia V.
Chumachenko, Yaroslav D.
Obukhova, Olha A.
Martsovenko, Igor
Harbuzova, Viktoriia Yu.
Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population
title Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population
title_full Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population
title_fullStr Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population
title_full_unstemmed Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population
title_short Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population
title_sort impact of mmp-9 genetic polymorphism and concentration on the development of coronary artery disease in ukrainian population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017573/
https://www.ncbi.nlm.nih.gov/pubmed/35449607
http://dx.doi.org/10.1155/2022/2067632
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