Identification, Efficacy, and Stability Evaluation of Succinimide Modification With a High Abundance in the Framework Region of Golimumab

Succinimide (Asu) is the intermediate for asparagine deamidation in therapeutic proteins, and it can be readily hydrolyzed to form aspartate and iso-aspartate residues. Moreover, Asu plays an important role in the protein degradation pathways, asparagine deamidation, and aspartic acid isomerization....

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Detalles Bibliográficos
Autores principales: Liu, Tao, Xu, Jin, Guo, Qingcheng, Zhang, Dapeng, Li, Jun, Qian, Weizhu, Guo, Huaizu, Zhou, Xinli, Hou, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017650/
https://www.ncbi.nlm.nih.gov/pubmed/35449588
http://dx.doi.org/10.3389/fchem.2022.826923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017650/
https://www.ncbi.nlm.nih.gov/pubmed/35449588
http://dx.doi.org/10.3389/fchem.2022.826923

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