Hypoxia and Hypoxia-Inducible Factors in Lymphedema

Lymphedema is a chronic inflammatory disorder characterized by edema, fat deposition, and fibrotic tissue remodeling. Despite significant advances in lymphatic biology research, our knowledge of lymphedema pathology is incomplete. Currently, there is no approved pharmacological therapy for this debi...

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Autores principales: Jiang, Xinguo, Tian, Wen, Kim, Dongeon, McQuiston, Alexander S., Vinh, Ryan, Rockson, Stanley G., Semenza, Gregg L., Nicolls, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017680/
https://www.ncbi.nlm.nih.gov/pubmed/35450048
http://dx.doi.org/10.3389/fphar.2022.851057
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author Jiang, Xinguo
Tian, Wen
Kim, Dongeon
McQuiston, Alexander S.
Vinh, Ryan
Rockson, Stanley G.
Semenza, Gregg L.
Nicolls, Mark R.
author_facet Jiang, Xinguo
Tian, Wen
Kim, Dongeon
McQuiston, Alexander S.
Vinh, Ryan
Rockson, Stanley G.
Semenza, Gregg L.
Nicolls, Mark R.
author_sort Jiang, Xinguo
collection PubMed
description Lymphedema is a chronic inflammatory disorder characterized by edema, fat deposition, and fibrotic tissue remodeling. Despite significant advances in lymphatic biology research, our knowledge of lymphedema pathology is incomplete. Currently, there is no approved pharmacological therapy for this debilitating disease. Hypoxia is a recognized feature of inflammation, obesity, and fibrosis. Understanding hypoxia-regulated pathways in lymphedema may provide new insights into the pathobiology of this chronic disorder and help develop new medicinal treatments.
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spelling pubmed-90176802022-04-20 Hypoxia and Hypoxia-Inducible Factors in Lymphedema Jiang, Xinguo Tian, Wen Kim, Dongeon McQuiston, Alexander S. Vinh, Ryan Rockson, Stanley G. Semenza, Gregg L. Nicolls, Mark R. Front Pharmacol Pharmacology Lymphedema is a chronic inflammatory disorder characterized by edema, fat deposition, and fibrotic tissue remodeling. Despite significant advances in lymphatic biology research, our knowledge of lymphedema pathology is incomplete. Currently, there is no approved pharmacological therapy for this debilitating disease. Hypoxia is a recognized feature of inflammation, obesity, and fibrosis. Understanding hypoxia-regulated pathways in lymphedema may provide new insights into the pathobiology of this chronic disorder and help develop new medicinal treatments. Frontiers Media S.A. 2022-03-28 /pmc/articles/PMC9017680/ /pubmed/35450048 http://dx.doi.org/10.3389/fphar.2022.851057 Text en Copyright © 2022 Jiang, Tian, Kim, McQuiston, Vinh, Rockson, Semenza and Nicolls. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Jiang, Xinguo
Tian, Wen
Kim, Dongeon
McQuiston, Alexander S.
Vinh, Ryan
Rockson, Stanley G.
Semenza, Gregg L.
Nicolls, Mark R.
Hypoxia and Hypoxia-Inducible Factors in Lymphedema
title Hypoxia and Hypoxia-Inducible Factors in Lymphedema
title_full Hypoxia and Hypoxia-Inducible Factors in Lymphedema
title_fullStr Hypoxia and Hypoxia-Inducible Factors in Lymphedema
title_full_unstemmed Hypoxia and Hypoxia-Inducible Factors in Lymphedema
title_short Hypoxia and Hypoxia-Inducible Factors in Lymphedema
title_sort hypoxia and hypoxia-inducible factors in lymphedema
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017680/
https://www.ncbi.nlm.nih.gov/pubmed/35450048
http://dx.doi.org/10.3389/fphar.2022.851057
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