Chondrogenesis with Autologous Peripheral Blood Stem Cells for End-Stage Ankle Arthritis: Report of Three Cases

End-stage ankle arthritis represents an “unmet medical need”, awaiting an appropriate time for joint arthroplasty or arthrodesis. We report three cases of end-stage ankle arthritis treated along the principles developed for chondrogenesis of the knee joint with autologous peripheral blood stem cells...

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Autores principales: Saw, KY, Anz, AW, Jee, CSY, Ramlan, A, Dawam, A, Low, SF
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Malaysian Orthopaedic Association 2022
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017926/
https://www.ncbi.nlm.nih.gov/pubmed/35519540
http://dx.doi.org/10.5704/MOJ.2203.022
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author Saw, KY
Anz, AW
Jee, CSY
Ramlan, A
Dawam, A
Low, SF
author_facet Saw, KY
Anz, AW
Jee, CSY
Ramlan, A
Dawam, A
Low, SF
author_sort Saw, KY
collection PubMed
description End-stage ankle arthritis represents an “unmet medical need”, awaiting an appropriate time for joint arthroplasty or arthrodesis. We report three cases of end-stage ankle arthritis treated along the principles developed for chondrogenesis of the knee joint with autologous peripheral blood stem cells, resulting in reversal of the ankle arthritis. The improvement in clinical outcome measure scores (Ankle Osteoarthritis Scale total score) with a minimum two-year follow-up were comparable to total ankle replacement (TAR), arthroscopic ankle arthrodesis (AAA) and open ankle arthrodesis (OAA).
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spelling pubmed-90179262022-05-04 Chondrogenesis with Autologous Peripheral Blood Stem Cells for End-Stage Ankle Arthritis: Report of Three Cases Saw, KY Anz, AW Jee, CSY Ramlan, A Dawam, A Low, SF Malays Orthop J Case Reports End-stage ankle arthritis represents an “unmet medical need”, awaiting an appropriate time for joint arthroplasty or arthrodesis. We report three cases of end-stage ankle arthritis treated along the principles developed for chondrogenesis of the knee joint with autologous peripheral blood stem cells, resulting in reversal of the ankle arthritis. The improvement in clinical outcome measure scores (Ankle Osteoarthritis Scale total score) with a minimum two-year follow-up were comparable to total ankle replacement (TAR), arthroscopic ankle arthrodesis (AAA) and open ankle arthrodesis (OAA). Malaysian Orthopaedic Association 2022-03 /pmc/articles/PMC9017926/ /pubmed/35519540 http://dx.doi.org/10.5704/MOJ.2203.022 Text en © 2022 Malaysian Orthopaedic Association MOA. All Rights Reserved https://creativecommons.org/licenses/by/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
spellingShingle Case Reports
Saw, KY
Anz, AW
Jee, CSY
Ramlan, A
Dawam, A
Low, SF
Chondrogenesis with Autologous Peripheral Blood Stem Cells for End-Stage Ankle Arthritis: Report of Three Cases
title Chondrogenesis with Autologous Peripheral Blood Stem Cells for End-Stage Ankle Arthritis: Report of Three Cases
title_full Chondrogenesis with Autologous Peripheral Blood Stem Cells for End-Stage Ankle Arthritis: Report of Three Cases
title_fullStr Chondrogenesis with Autologous Peripheral Blood Stem Cells for End-Stage Ankle Arthritis: Report of Three Cases
title_full_unstemmed Chondrogenesis with Autologous Peripheral Blood Stem Cells for End-Stage Ankle Arthritis: Report of Three Cases
title_short Chondrogenesis with Autologous Peripheral Blood Stem Cells for End-Stage Ankle Arthritis: Report of Three Cases
title_sort chondrogenesis with autologous peripheral blood stem cells for end-stage ankle arthritis: report of three cases
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017926/
https://www.ncbi.nlm.nih.gov/pubmed/35519540
http://dx.doi.org/10.5704/MOJ.2203.022
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